Tubular surgical patch and preparation method thereof
A surgical and tubular technology, applied in the field of tubular surgical patch and its preparation, can solve the problems of inhibiting the normal growth of repaired tissue, difficult to control the degradation rate, synchronization of repairing speed, postoperative restenosis, etc., to achieve safe use and meet mechanical requirements , good biocompatibility
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Embodiment 1
[0031] Embodiment 1, the preparation of tubular surgical patch
[0032] 1. Collect the esophagus of adult pigs that have just been slaughtered from slaughterhouses under standardized management, try to avoid contact with pollutants, and freeze them immediately after collection.
[0033] 2. Thaw the esophagus obtained in step 1 and fully wash it, peel off the muscle tissue, and take the middle section with a length of about 15-20cm and a uniform diameter.
[0034] 3. Decellularization treatment
[0035] Use a surfactant solution to soak the product of step 2.
[0036] The purpose of this step is to destroy the cell membrane structure and break up and dissolve the cells.
[0037] Specific steps: Soak in 0.5g / 100ml TritonX-100 aqueous solution at 8±2°C for 15 hours, then wash with water.
[0038] 4. The first alkali treatment
[0039] Use alkaline solution to soak the product of step 3.
[0040] The purpose of this step is to denature, hydrolyze and dissolve the non-collagen...
Embodiment 2
[0061] Embodiment 2, the preparation of tubular surgical patch
[0062] 1. Collect the esophagus of adult cattle that have just been slaughtered from slaughterhouses under standardized management, avoid contact with pollutants as much as possible, and freeze and store immediately after collection.
[0063] 2. Thaw the esophagus obtained in step 1 and fully wash it, peel off the muscle tissue, and take the middle section with a length of about 15-20cm and a uniform diameter.
[0064] 3. Decellularization treatment
[0065] Use a surfactant solution to soak the product of step 2.
[0066] The purpose of this step is to destroy the cell membrane structure and break up and dissolve the cells.
[0067] Specific steps: Soak with 1g / 100ml Tween-80 aqueous solution at 23±2°C for 1 hour, and then wash with water.
[0068] 4. The first alkali treatment
[0069] Use alkaline solution to soak the product of step 3.
[0070] The purpose of this step is to denature, hydrolyze and disso...
Embodiment 3
[0091] Embodiment 3, the preparation of tubular surgical patch
[0092] 1. Collect the esophagus of adult pigs that have just been slaughtered from slaughterhouses under standardized management, try to avoid contact with pollutants, and freeze them immediately after collection.
[0093] 2. Thaw the esophagus obtained in step 1 and fully wash it, peel off the muscle tissue, and take the middle section with a length of about 15-20cm and a uniform diameter.
[0094] 3. Decellularization treatment
[0095] Use a surfactant solution to soak the product of step 2.
[0096] The purpose of this step is to destroy the cell membrane structure and break up and dissolve the cells.
[0097] Specific steps: Soak with 3g / 100ml Tween-40 aqueous solution at 2±2°C for 168 hours, and then wash with water.
[0098] 4. The first alkali treatment
[0099] Use alkaline solution to soak the product of step 3.
[0100] The purpose of this step is to denature, hydrolyze and dissolve the non-collag...
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