Tubular surgical patch and preparation method thereof

A surgical and tubular technology, applied in the field of tubular surgical patch and its preparation, can solve the problems of inhibiting the normal growth of repaired tissue, difficult to control the degradation rate, synchronization of repairing speed, postoperative restenosis, etc., to achieve safe use and meet mechanical requirements , good biocompatibility

Active Publication Date: 2014-11-19
YANTAI ZHENGHAI BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The new materials used to make "surgical patches" include polyglycolic acid, polylactic acid and their copolymers, etc., but it is difficult to control their degradation rate to synchronize with the tissue repair rate. Postoperative restenosis caused by excessive degradation is the reason A major disadvantage of similar repair materials, while the degradation products cause local strong acidity, inhibiting the normal growth of the repaired tissue

Method used

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  • Tubular surgical patch and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1, the preparation of tubular surgical patch

[0032] 1. Collect the esophagus of adult pigs that have just been slaughtered from slaughterhouses under standardized management, try to avoid contact with pollutants, and freeze them immediately after collection.

[0033] 2. Thaw the esophagus obtained in step 1 and fully wash it, peel off the muscle tissue, and take the middle section with a length of about 15-20cm and a uniform diameter.

[0034] 3. Decellularization treatment

[0035] Use a surfactant solution to soak the product of step 2.

[0036] The purpose of this step is to destroy the cell membrane structure and break up and dissolve the cells.

[0037] Specific steps: Soak in 0.5g / 100ml TritonX-100 aqueous solution at 8±2°C for 15 hours, then wash with water.

[0038] 4. The first alkali treatment

[0039] Use alkaline solution to soak the product of step 3.

[0040] The purpose of this step is to denature, hydrolyze and dissolve the non-collagen...

Embodiment 2

[0061] Embodiment 2, the preparation of tubular surgical patch

[0062] 1. Collect the esophagus of adult cattle that have just been slaughtered from slaughterhouses under standardized management, avoid contact with pollutants as much as possible, and freeze and store immediately after collection.

[0063] 2. Thaw the esophagus obtained in step 1 and fully wash it, peel off the muscle tissue, and take the middle section with a length of about 15-20cm and a uniform diameter.

[0064] 3. Decellularization treatment

[0065] Use a surfactant solution to soak the product of step 2.

[0066] The purpose of this step is to destroy the cell membrane structure and break up and dissolve the cells.

[0067] Specific steps: Soak with 1g / 100ml Tween-80 aqueous solution at 23±2°C for 1 hour, and then wash with water.

[0068] 4. The first alkali treatment

[0069] Use alkaline solution to soak the product of step 3.

[0070] The purpose of this step is to denature, hydrolyze and disso...

Embodiment 3

[0091] Embodiment 3, the preparation of tubular surgical patch

[0092] 1. Collect the esophagus of adult pigs that have just been slaughtered from slaughterhouses under standardized management, try to avoid contact with pollutants, and freeze them immediately after collection.

[0093] 2. Thaw the esophagus obtained in step 1 and fully wash it, peel off the muscle tissue, and take the middle section with a length of about 15-20cm and a uniform diameter.

[0094] 3. Decellularization treatment

[0095] Use a surfactant solution to soak the product of step 2.

[0096] The purpose of this step is to destroy the cell membrane structure and break up and dissolve the cells.

[0097] Specific steps: Soak with 3g / 100ml Tween-40 aqueous solution at 2±2°C for 168 hours, and then wash with water.

[0098] 4. The first alkali treatment

[0099] Use alkaline solution to soak the product of step 3.

[0100] The purpose of this step is to denature, hydrolyze and dissolve the non-collag...

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Abstract

The invention discloses a tubular surgical patch and a preparation method thereof. The method for preparing the tubular surgical patch, provided by the invention, comprises the following steps of: (1) soaking and treating an isolated animal tubular membrane tissue by using a surface active agent solution; (2) soaking and treating the product of step (1) by using aqueous alkali; (3) soaking and treating the product of step (2) by using the surface active agent solution; (4) soaking and treating the product of step (3) by using the aqueous alkali; (5) soaking and treating the product of step (4) by using an ethylene glycol solution; (6) soaking and treating the product of step (5) by using an H2O2 solution; (7) soaking and treating the product of step (6) by using an irradiation protection reagent solution of which the pH is 5.8-7.8; and (8) performing freeze drying and irradiation sterilization on the product of step (7) in sequence so as to obtain the tubular surgical patch. The method disclosed by the invention has the advantages of no immune rejection reaction, having good biocompatibility and satisfying mechanical requirements of repaired tissues.

Description

technical field [0001] The invention belongs to the field of implanted medical devices, in particular to a tubular surgical patch used for repairing tissues and organs in surgical operations and a preparation method thereof. Background technique [0002] In modern surgical operations, it is often necessary to repair some defective tissues and organs, such as the repair of dura / spinal defects. In order to meet the needs of these repairs, there are currently a variety of "surgical patches" in China to supply clinical needs. [0003] Most of the existing tubular materials are made of chemical synthetic materials. The existing materials used to make "surgical patches" include: polypropylene, polyethylene, polyamide, polyester resin, polytetrafluoroethylene, silicone rubber, Carbon fibers, etc., are foreign bodies to biological organisms. If they exist in the repaired tissue for a long time, they will cause aseptic inflammation caused by physical stimulation and sequelae caused ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/36A61L27/24
Inventor 董佳桓马百聚蒋绍霞孙先昌刘涛张素花
Owner YANTAI ZHENGHAI BIO TECH
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