Tubular surgical patch and preparation method thereof

A surgical and tubular technology, applied in the field of tubular surgical patch and its preparation, can solve the problems of postoperative restenosis, inhibit the normal growth of repair tissue, it is difficult to control the degradation speed and repair speed synchronization, etc., to achieve good biocompatibility, The effect of safe use and meeting the mechanical requirements

Active Publication Date: 2013-09-04
YANTAI ZHENGHAI BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The new materials used to make "surgical patches" include polyglycolic acid, polylactic acid and their copolymers, etc., but it is difficult to control their degradation rate to synchronize with the tissue repair rate. Postoperative restenosis caused by excessive degradation is the reason A major disadvantage of similar repair materials, while the degradation products cause local strong acidity, inhibiting the normal growth of the repaired tissue

Method used

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  • Tubular surgical patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1. Preparation of tubular surgical patch

[0032] 1. Collect the esophagus of adult pigs that have just been slaughtered from a standardized management slaughter plant, try to avoid contact with pollutants, and freeze and store immediately after collection.

[0033] 2. Thaw the esophagus obtained in step 1 and wash it thoroughly, peel off the muscle tissue, and take the part of the middle section with a length of about 15-20 cm and a uniform tube diameter.

[0034] 3. Decellularization treatment

[0035] The product of step 2 is immersed in a surfactant solution.

[0036] The purpose of this step is to destroy the cell membrane structure and break the cells to dissolve.

[0037] Specific steps: Use 0.5g / 100ml TritonX-100 aqueous solution to soak at 8±2℃ for 15 hours, then wash with water.

[0038] 4. The first alkali treatment

[0039] The product of step 3 is soaked in an alkaline solution.

[0040] The purpose of this step is to denature, hydrolyze, and dissolve the non-col...

Embodiment 2

[0061] Example 2. Preparation of Tubular Surgical Patch

[0062] 1. Collect the esophagus of the adult cattle that has just been slaughtered from a standardized management slaughter plant, try to avoid contact with contaminants, and freeze and store immediately after collection.

[0063] 2. Thaw the esophagus obtained in step 1 and wash it thoroughly, peel off the muscle tissue, and take the part of the middle section with a length of about 15-20 cm and a uniform tube diameter.

[0064] 3. Decellularization treatment

[0065] The product of step 2 is immersed in a surfactant solution.

[0066] The purpose of this step is to destroy the cell membrane structure and break the cells to dissolve.

[0067] Specific steps: Use 1g / 100ml Tween-80 aqueous solution at 23±2℃ to soak for 1 hour, then wash with water.

[0068] 4. The first alkali treatment

[0069] The product of step 3 is soaked in an alkaline solution.

[0070] The purpose of this step is to denature, hydrolyze, and dissolve the non-co...

Embodiment 3

[0091] Example 3. Preparation of tubular surgical patch

[0092] 1. Collect the esophagus of adult pigs that have just been slaughtered from a standardized management slaughter plant, try to avoid contact with pollutants, and freeze and store immediately after collection.

[0093] 2. Thaw the esophagus obtained in step 1 and wash it thoroughly, peel off the muscle tissue, and take the part of the middle section with a length of about 15-20 cm and a uniform tube diameter.

[0094] 3. Decellularization treatment

[0095] The product of step 2 is immersed in a surfactant solution.

[0096] The purpose of this step is to destroy the cell membrane structure and break the cells to dissolve.

[0097] Specific steps: Use 3g / 100ml Tween-40 aqueous solution 2±2℃ to soak for 168 hours, then wash with water.

[0098] 4. The first alkali treatment

[0099] The product of step 3 is soaked in an alkaline solution.

[0100] The purpose of this step is to denature, hydrolyze, and dissolve the non-collagen p...

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Abstract

The invention discloses a tubular surgical patch and a preparation method thereof. The method for preparing the tubular surgical patch, provided by the invention, comprises the following steps of: (1) soaking and treating an isolated animal tubular membrane tissue by using a surface active agent solution; (2) soaking and treating the product of step (1) by using aqueous alkali; (3) soaking and treating the product of step (2) by using the surface active agent solution; (4) soaking and treating the product of step (3) by using the aqueous alkali; (5) soaking and treating the product of step (4) by using an ethylene glycol solution; (6) soaking and treating the product of step (5) by using an H2O2 solution; (7) soaking and treating the product of step (6) by using an irradiation protection reagent solution of which the pH is 5.8-7.8; and (8) performing freeze drying and irradiation sterilization on the product of step (7) in sequence so as to obtain the tubular surgical patch. The method disclosed by the invention has the advantages of no immune rejection reaction, having good biocompatibility and satisfying mechanical requirements of repaired tissues.

Description

Technical field [0001] The invention belongs to the field of implanted medical devices, and particularly relates to a tubular surgical patch used for repairing tissues and organs in surgical operations and a preparation method thereof. Background technique [0002] In modern surgical operations, it is often necessary to repair some defective tissues and organs, such as the repair of dural / spine defects. In order to meet the needs of these repairs, there are currently a variety of "surgical patches" for clinical needs in China. [0003] Most of the existing tubular materials are made of chemical synthetic materials. The existing materials used to make "surgical patches" include: polypropylene, polyethylene, polyamide, polyester resin, polytetrafluoroethylene, silicone rubber, Carbon fiber, etc., are foreign bodies to the organism. If they exist in the repaired tissue for a long time, it will cause aseptic inflammation caused by physical stimulation and sequelae caused by chronic re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/24
Inventor 董佳桓马百聚蒋绍霞孙先昌刘涛张素花
Owner YANTAI ZHENGHAI BIO TECH
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