Particle counting system of micro-fluidic chip based on electric resistance technology

A microfluidic chip and electrical impedance technology, applied in the field of electrical detection, can solve problems such as high cost burden, inability to meet portability, and low signal-to-noise ratio

Inactive Publication Date: 2013-09-25
BEIJING INSTITUTE OF TECHNOLOGYGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At the same time, in the current microfluidic chip particle counting device, due to the low signal-to-noise ratio, the detection system generally adopts more complicated technologies, such as synchronous detection technology, or uses

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  • Particle counting system of micro-fluidic chip based on electric resistance technology
  • Particle counting system of micro-fluidic chip based on electric resistance technology
  • Particle counting system of micro-fluidic chip based on electric resistance technology

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Embodiment Construction

[0044] The present invention will be described in detail below with reference to the accompanying drawings and examples.

[0045] This embodiment provides a microfluidic chip particle counting system based on electrical impedance technology. This system uses common conductive metal needles as the electrodes of the microfluidic chip, and uses the method of signal differential detection to detect its impedance signal. The chip manufacturing process is simple, low in cost and easy to carry.

[0046] The system includes a microfluidic chip and a signal detection circuit. The microfluidic chip includes: a glass substrate, a PDMS (polydimethylsiloxane) substrate and two pairs of metal needles used as electrodes. The signal detection circuit includes: two I / V conversion circuits, a differential circuit, an envelope detection circuit, a high-pass filter circuit, a low-pass filter circuit and an amplification circuit. The overall connection relationship of the system is as follows: A...

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Abstract

The invention discloses a particle counting system of a micro-fluidic chip based on an electric resistance technology. The system comprises a micro-fluidic chip and a signal detection circuit. The micro-fluidic chip comprises a glass substrate, a PDMS substrate and two pairs of metal needles used as electrodes. Normal conductive metal needles are utilized as the electrodes of the micro-fluidic chip to produce an electric field which is across a micro-channel, therefore the preparation process of the micro-fluidic chip is comparatively simple and the production cost is comparatively low. The signal detection circuit comprises two I/V conversion circuit, a differential circuit, an envelope detection circuit, a high-pass filter circuit, a low-pass filter circuit and an amplifying circuit. The resistance signals are detected in the signal detection circuit by utilizing signal differential detection method to ensure precision of signal detection.

Description

technical field [0001] The invention relates to a particle counting system, in particular to a microfluidic chip particle counting system based on electrical impedance technology, which belongs to the technical field of electrical detection. Background technique [0002] Electrical impedance counting technology is the earliest automated technology for particle / cell counting. Since the particles / cells can be regarded as insulating objects to a certain extent, when the particles / cells pass through the electric field in a certain fixed area, the impedance of the fixed electric field area will increase; when the particles / cells leave the electric field area, the impedance will return to normal ; The size of the impedance signal is proportional to the volume of the particle / cell. Therefore, people use this feature to count and classify particles / cells. However, the current commercial electrical impedance counters are generally relatively large and cannot meet the requirements o...

Claims

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Application Information

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IPC IPC(8): G01N15/10B01L3/00
Inventor 刘志文周治国王群范哲意梅哲
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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