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New applications of aildenafil and salts thereof

A technology of use, citrate, applied in the direction of medical preparations containing active ingredients, applications, food science, etc., can solve problems such as quality of life not including sexual life

Inactive Publication Date: 2013-12-04
陈凯
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it does not include use to treat female sexual dysfunction or to improve the quality of sex life

Method used

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  • New applications of aildenafil and salts thereof
  • New applications of aildenafil and salts thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0010] Example Aldenafil citrate

[0011] Aldenafil reacts with citric acid under reflux in absolute ethanol to generate Aldenafil citrate. The chemical name of edenafil citrate is: 1-[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3- d] pyrimidin-5-yl)-4-ethoxybenzenesulfonyl]-cis-3,5-dimethylpiperazine citrate, molecular weight: 680.74, molecular formula: C 23 h 32 N 6 O4 S ·C 6 h 8 o 7 , the chemical reaction formula is as follows:

[0012]

[0013] Aldenafil citrate and lactose, microcrystalline cellulose, magnesium stearate, and crospovidone are made into tablets, that is, aldenafil citrate tablets. The tablet has a remarkable effect on treating female sexual dysfunction. For example, taking a tablet containing 42 mg of edenafil citrate can effectively arouse female sexual desire, improve sexual pleasure, and increase estrogen levels in the body.

[0014] Safety: LD of edenafil citrate administered to female mice 50 1002mg / kg, intraperitoneal LD ​​of fe...

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PUM

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Abstract

The invention discloses new applications of aildenafil and salts thereof. The compound aildenafil and / or the salts thereof can be used to prepared medicines, health products or foodstuffs for improving female sexual dysfunction, promoting female sexual desire and improving female sexual life quality.

Description

technical field [0001] The present invention relates to the new application of ardenafil and its salt, and the medicine, health product or food containing ardenafil and / or its salt of the present invention is used to improve female sexual dysfunction, promote female sexual desire, and improve female sexual life quality . Background technique [0002] Female sexual dysfunction includes: (1) sexual desire disorders (sexual desire disorders), including hyporesponsive sexual function and sexual aversion. Hyporesponsive sexual desire disorder refers to persistent or recurrent sexual fantasies or low or absent libido that cause psychological distress. Sexual aversion refers to persistent or recurrent phobic aversion and avoidance of sexual contact with sexual partners, which causes psychological distress; (2) sexual arousal disorders (sexual arousal disorders) refer to persistent or recurrent inability to obtain or maintain sufficient sexual arousal, and cause psychological dist...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/519A61P15/00A23L1/29A23L33/00
Inventor 陈凯
Owner 陈凯
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