Applications of traditional Aidi Chinese medicine composition and preparations thereof in preparing drugs for curing depression

A composition and technology for depression, applied in drug combinations, medical raw materials derived from arthropods, pharmaceutical formulations, etc., can solve problems such as patent literature and research reports that have no therapeutic effect

Inactive Publication Date: 2013-12-04
GUIZHOU YIBAI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although previous studies have shown that Aidi preparations can be used to prepare drugs for treating tumors, regulating immunit...

Method used

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  • Applications of traditional Aidi Chinese medicine composition and preparations thereof in preparing drugs for curing depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] (1) Weigh the raw materials according to the following proportions:

[0065] Ginseng 500g, Cantharidin 15g, Astragalus 1000g, Acanthopanax 1500g

[0066] (2) Preparation method:

[0067] The above four flavors, ginseng slices, were extracted twice with 50% ethanol by heating and refluxing, the first time was 3 hours, the second time was 1.5 hours, the extracts were combined, filtered, the ethanol was recovered, and the liquid was used for use; Add water and cook for three times, the first time is 3 hours, the second time is 1.5 hours, the third time is 1 hour, the decoction is combined, filtered, the filtrate is combined with the ginseng extract, and the lime sulfur method is used for precipitation treatment twice, and the obtained supernatant is Add ethanol to make the alcohol content reach 80%, let stand overnight, take the supernatant under reduced pressure to recover ethanol until there is no alcohol smell, and then obtain the traditional Chinese medicine extract. ...

Embodiment 2

[0069] (1) Weigh the raw materials according to the following proportions:

[0070] Ginseng 500g, Cantharidin 10g, Astragalus 1000g, Acanthopanax 2000g

[0071] (2) Preparation method:

[0072] The cantharidin medicinal materials were taken, crushed, and extracted with 400ml 100% ethanol under reflux for 5 times. The solution was adjusted to pH 8-9, ethanol was recovered under reduced pressure, filtered, diluted with water to 1000ml, adjusted to pH 6-7 with 12% hydrochloric acid solution, left to stand, refrigerated, centrifuged, and the supernatant was used 4% sodium hydroxide solution Adjusted to pH 8-9 for later use; take ginseng slices, extract with 480ml of 60% ethanol under reflux for 3 hours, filter, and use the dregs for later use, extract ethanol under reduced pressure, add water to the concentrated solution to a volume of 150ml, apply macroporous adsorption resin, Add water to elute 5 times the column volume, and then use 80% ethanol to elute 5 times the column vol...

Embodiment 3

[0074] (1) Weigh the raw materials according to the following proportions:

[0075] Ginseng 500g, Cantharidin 10g, Astragalus 1000g, Acanthopanax 2000g

[0076] (2) Preparation method:

[0077] The ginseng slices were extracted twice with 200ml of 95% ethanol under heating and reflux. The extraction time was: 2h and 1h. The extracts were combined, filtered, and the ethanol was recovered under reduced pressure. Mix and boil 3 times, the extraction time is: 2h, 1h, 0.5h respectively, filter, combine the filtrate with the ginseng extract, precipitation by the lime sulfur method, and add 95% ethanol to the obtained supernatant to precipitate, so that the alcohol content reaches 60%, let stand for 48 hours, take the supernatant and recover ethanol under reduced pressure until there is no alcohol smell, and obtain the traditional Chinese medicine extract.

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Abstract

The invention relates to applications of Aidi traditional Chinese medicine composition and preparations thereof in preparing drugs for curing depression, especially applications in preparing drugs for curing tumor related depression. The Aidi traditional Chinese medicine composition is composed of four medicines as follows: gen-seng, mylabris, radix astragali, and acanthopanax. An Aidi preparation is prepared by adding corresponding auxiliary materials on the basis of the traditional Chinese medicine composition through adopting conventional methods. The invention provides a novel cure drug for depression, and enlarges the clinical application area of Aidi preparations.

Description

technical field [0001] The invention relates to new uses of Aidi traditional Chinese medicine compositions and preparations thereof in the preparation of medicines for treating depression, especially the use in preparing medicines for treating depression in tumor patients. technical background [0002] Depression is an affective disorder. It is a group of psychological or affective disorders with depression as the main symptom caused by various reasons. The clinical manifestations are depression, loss of interest, low self-evaluation, pessimism about the future, Unwilling to take the initiative to interact with people, etc. Often accompanied by corresponding changes in thinking and behavior, some patients will experience hallucinations and delusions, and severe cases are accompanied by suicidal behavior, which seriously affects people's quality of life. Most cases tend to have recurrent attacks, most of which can be relieved each time the attack occurs, and some may have re...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61P25/24A61K35/64
Inventor 窦啟玲张宝鹤周炜杜卓叶红霞
Owner GUIZHOU YIBAI PHARMA CO LTD
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