Pharmaceutical composition capable of improving cognitive ability, preparation method and applications thereof

A technology to improve cognition and composition, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of large amount of prescriptions, unfavorable long-term use of patients, and lack of precious medicinal materials, etc., to achieve low cost, Applicable to a wide range of people, conducive to the effect of promotion

Active Publication Date: 2014-05-28
SICHUAN ACAD OF CHINESE MEDICINE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these traditional Chinese medicine compound prescriptions have many flavors, a large amount of prescriptions, and there are many precious medicinal materials, which are not conducive to the long-term use of patients.

Method used

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  • Pharmaceutical composition capable of improving cognitive ability, preparation method and applications thereof
  • Pharmaceutical composition capable of improving cognitive ability, preparation method and applications thereof
  • Pharmaceutical composition capable of improving cognitive ability, preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037]Take Radix Polygonum multiflorum 5kg, Epimedium 10kg, Salvia miltiorrhiza 5kg, Cornus officinalis 10kg, Ginseng 5kg, reflux and extract twice with water, add 12 times the amount for the first time, add 10 times the amount for the second time, reflux for 2 hours each time, filter , combine the filtrates, concentrate to a relative density of about 1.25, add ethanol to make the content of alcohol reach about 80%, let stand and separate the alcohol precipitation liquid obtained by solid-liquid separation, recover ethanol, concentrate and dry, and the obtained extract is crushed through a 60-mesh sieve, Add appropriate amount of auxiliary materials, mix evenly, compress into tablets according to conventional preparation methods, and coat to obtain.

Embodiment 2

[0039] Take 9 kg of Polygonum multiflorum, add water and reflux to extract 3 times, add 10 times the amount for the first time, reflux for 2 hours, add 8 times the amount for the second and third times, reflux for 1 hour, filter, combine the filtrates, and concentrate to the relative The density is about 1.20, add ethanol to make the alcohol content reach about 70%, let stand and separate the solid and liquid.

[0040] Take another 6kg of Epimedium, 6kg of Salvia, 6kg of Cornus officinalis, and 2kg of Ginseng, add water and reflux to extract twice, add 12 times the amount for the first time, add 10 times the amount for the second time, reflux for 2 hours each time, filter, and combine the filtrates. Put on the HPD100 macroporous adsorption resin column, first wash and remove impurities with 2-3 times the column volume of water, then elute with 70% ethanol about 3 times the column volume, collect the ethanol eluate, and separate it from the solid-liquid of Shouwu Liquids are co...

Embodiment 3

[0042] Take Radix Polygoni Multiflori 15kg, Epimedium 5kg, Salvia miltiorrhiza 10kg, Cornus officinalis 5kg, Ginseng 1kg, add 60% ethanol to reflux extraction for 3 times, add 8 times the amount for the first time, add 6 times the amount for the second and third times respectively, Reflux for 1 to 2 hours each time, filter, combine filtrates, recover ethanol, concentrate, and dry, grind the obtained extract, add appropriate amount of auxiliary materials, mix evenly, and make pills according to conventional preparation methods.

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PUM

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Abstract

The invention provides a pharmaceutical composition capable of improving the cognitive ability. The pharmaceutical composition is a preparation composed of the following medicinal raw materials in parts by weight: 5 to 15 parts of processed fleece-flower root, 5 to 10 parts of epimedium, 5 to 10 parts of red sage root, 5 to 10 parts of cornus officinalis, and 1 to 5 parts of ginseng. The pharmaceutical composition is prepared by compounding drugs such as fleece-flower root, and the like; experiments has shown that the pharmaceutical composition can improve the cognitive disorder caused by aging, cerebrovascular accidents, or the like, such as learning and memory ability degradation, and the like; can be used to treat and prevent mild cognitive disorder and dementia, and is capable of controlling the disease progression and relieving the clinical symptoms.

Description

technical field [0001] The invention relates to a pharmaceutical composition for improving cognitive ability, its preparation method and application. Background technique [0002] Dementia is a progressive degeneration of cognitive function caused by brain injury or disease. The degree of degeneration is much higher than the progress of normal aging, especially affecting memory, attention, language, problem-solving ability, etc., in severe cases Will be unable to distinguish between people and things. Alzheimer's disease (AD) is the main type of dementia, which also includes other types such as vascular dementia (VD) and mixed dementia. AD is a degenerative disease of the central nervous system that occurs in the elderly and middle-aged and is characterized by progressive cognitive dysfunction and behavioral impairment. Once it occurs, it is difficult to reverse, and clinical treatment can only delay the process. VD refers to severe cognitive dysfunction syndrome caused by...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/704A61P25/28
Inventor 李东晓易进海张毅苏琛雷玲吴瑕刘云华刘玉红胡竟一
Owner SICHUAN ACAD OF CHINESE MEDICINE SCI
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