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Dual-core platinum complex having anti-tumor activity and preparation method thereof

An anti-tumor activity, dual-core platinum technology, applied in the field of medicine, can solve the problems of myelosuppression, narrow anti-cancer spectrum, and large toxic and side effects

Inactive Publication Date: 2014-06-18
KUNMING GUIYAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the drugs currently on the market also have many inherent shortcomings: large toxic and side effects, can cause nausea, vomiting, bone marrow suppression, etc., cross-resistance between each other, and narrow anti-cancer spectrum, etc. These shortcomings limit their wider application. use

Method used

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  • Dual-core platinum complex having anti-tumor activity and preparation method thereof
  • Dual-core platinum complex having anti-tumor activity and preparation method thereof
  • Dual-core platinum complex having anti-tumor activity and preparation method thereof

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Embodiment Construction

[0023] Preparation of the platinum complex of the present invention:

[0024] Reagents used: Potassium chloroplatinite with a purity of not less than 98%, commercially available analytically pure dimethyl sulfoxide, commercially available analytically pure (1R,2R)-1,2-cyclohexanediamine, commercially available analytically pure silver nitrate, Commercially available analytically pure 1,4-dibutylamine, 1,5-dipentylamine, 1,6-dihexylamine, 1,7-diheptylamine.

[0025] The present invention is further illustrated below by examples. The examples of the present invention are given only to illustrate the present invention, not to limit the present invention. Therefore, any simple improvement to the present invention under the premise of the method of the present invention belongs to the protection scope of the present invention.

[0026] making process:

[0027] Preparation of compounds with n=4:

[0028] Take by weighing 8.3 grams (20mmol) of potassium chloroplatinite and dissol...

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Abstract

The invention discloses a dual-core platinum complex having anti-tumor activity and a preparation method thereof. The series of dual-core platinum complexes of the invention structurally comprise a chiral group (1R, 2R)-1,2-diaminocyclohexane, a platinum-sulphur bond is formed by the coordination of dimethyl sulfoxide and platinum, and the diamine compound is used for bridge-connecting platinum ions. The compound with the structure has good anti-tumor activity and the structural formula thereof is shown in the description.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to a binuclear platinum complex, which has antitumor activity. Background technique: [0002] Cancer is a disease that seriously threatens human health and life, and is the second leading cause of death in the world after cardiovascular and cerebrovascular diseases. In recent years, due to environmental deterioration, bad living habits and population aging and other factors, the incidence of cancer in my country has been increasing. Cancer has become one of the medical problems that human beings urgently need to overcome. [0003] In the 1960s, Rosenberg, a professor at Michigan State University in the United States, discovered that cisplatin has anticancer activity when studying the effect of DC electric field on the growth of Escherichia coli, and through clinical verification, cisplatin has good therapeutic effects on various tumors , thus opening up a new field of research on t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F15/00A61P35/00
Inventor 王庆琨普绍平
Owner KUNMING GUIYAN PHARMA
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