Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Platinum (II) complex with antitumor activity and preparation method thereof

An anti-tumor activity and complex technology, applied in the field of medicine, can solve the problems of bone marrow suppression, large toxic and side effects, and narrow anti-cancer spectrum.

Inactive Publication Date: 2012-09-12
KUNMING GUIYAN PHARMA
View PDF4 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the drugs currently on the market also have many inherent shortcomings: large toxic and side effects, can cause nausea, vomiting, bone marrow suppression, etc., cross-resistance between each other, and narrow anti-cancer spectrum, etc. These shortcomings limit their wider application. use

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Platinum (II) complex with antitumor activity and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0014] Preparation of the platinum complex of the present invention:

[0015] Reagents used: cis-diiodo-cyclopentylamine with a purity of not less than 98%, methylamine platinum (II), commercially available analytically pure silver nitrate, commercially available analytically pure gallic acid monohydrate, commercially available analytically pure absolute ethanol .

[0016] making process:

[0017] Cis-diiodo-cyclopentylamine and methylamine platinum (II) are prepared by the method reported in the literature (US4533502), and cis-diiodo-dicyclopentylamine platinum (II) is reacted in perchloric acid solution Until the yellow solid turns into a brown solid completely, react the brown solid in methylamine solution until it turns into a yellow solid completely.

[0018] Weigh 5.7g (0.01mmol) of cis-diiodo-cyclopentylamine, methylamine platinum (II) and add a small amount of purified water to stir into a suspension, weigh 3.4g (0.02mmol) of silver nitrate and dissolve it in purifie...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a platinum complex with a chemical name of cis-gallate cyclopentylamine, methylamine platinum (II), molecular formula of Pt(CNH5)(C5NH11)(C7H4O5) and molecular weight of 479. The compound has excellent antitumor activity. The structure of the complex is shown in the specification.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to a platinum complex, which has antitumor activity. Background technique [0002] Cancer is a disease that seriously threatens human health and life, and is the second leading cause of death in the world after cardiovascular and cerebrovascular diseases. In recent years, due to environmental deterioration, bad living habits and population aging and other factors, the incidence of cancer in my country has been increasing. Cancer has become one of the medical problems that human beings urgently need to overcome. [0003] In the 1960s, Rosenberg, a professor at Michigan State University in the United States, discovered that cisplatin has anticancer activity when studying the effect of DC electric field on the growth of Escherichia coli, and through clinical verification, cisplatin has good therapeutic effects on various tumors , thus opening up a new field of research on the anticanc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07F15/00A61P35/00A61P35/02
Inventor 王庆琨普绍平彭娟黄天俊王蒙刘凉萌
Owner KUNMING GUIYAN PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com