Platinum (II) complex with antitumor activity and preparation method thereof

An anti-tumor activity and complex technology, applied in the field of medicine, can solve the problems of bone marrow suppression, large toxic and side effects, and narrow anti-cancer spectrum.

Inactive Publication Date: 2012-09-12
KUNMING GUIYAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the drugs currently on the market also have many inherent shortcomings: large toxic and side effects, can cause nausea, vomiting, bone marrow suppression, etc., cross-resistance between each other, and narrow anti-cancer spectrum, etc. These shortcomings limit their wider application. use

Method used

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  • Platinum (II) complex with antitumor activity and preparation method thereof

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Experimental program
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Embodiment Construction

[0014] Preparation of the platinum complex of the present invention:

[0015] Reagents used: cis-diiodo-cyclopentylamine with a purity of not less than 98%, methylamine platinum (II), commercially available analytically pure silver nitrate, commercially available analytically pure gallic acid monohydrate, commercially available analytically pure absolute ethanol .

[0016] making process:

[0017] Cis-diiodo-cyclopentylamine and methylamine platinum (II) are prepared by the method reported in the literature (US4533502), and cis-diiodo-dicyclopentylamine platinum (II) is reacted in perchloric acid solution Until the yellow solid turns into a brown solid completely, react the brown solid in methylamine solution until it turns into a yellow solid completely.

[0018] Weigh 5.7g (0.01mmol) of cis-diiodo-cyclopentylamine, methylamine platinum (II) and add a small amount of purified water to stir into a suspension, weigh 3.4g (0.02mmol) of silver nitrate and dissolve it in purifie...

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Abstract

The invention provides a platinum complex with a chemical name of cis-gallate cyclopentylamine, methylamine platinum (II), molecular formula of Pt(CNH5)(C5NH11)(C7H4O5) and molecular weight of 479. The compound has excellent antitumor activity. The structure of the complex is shown in the specification.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to a platinum complex, which has antitumor activity. Background technique [0002] Cancer is a disease that seriously threatens human health and life, and is the second leading cause of death in the world after cardiovascular and cerebrovascular diseases. In recent years, due to environmental deterioration, bad living habits and population aging and other factors, the incidence of cancer in my country has been increasing. Cancer has become one of the medical problems that human beings urgently need to overcome. [0003] In the 1960s, Rosenberg, a professor at Michigan State University in the United States, discovered that cisplatin has anticancer activity when studying the effect of DC electric field on the growth of Escherichia coli, and through clinical verification, cisplatin has good therapeutic effects on various tumors , thus opening up a new field of research on the anticanc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F15/00A61P35/00A61P35/02
Inventor 王庆琨普绍平彭娟黄天俊王蒙刘凉萌
Owner KUNMING GUIYAN PHARMA
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