Dual inhibitor of met and vegf for treating cancer

A technology for bone cancer and prostate cancer, applied in the field of castration-resistant prostate cancer and bone metastases, can solve problems such as limited survival improvement

Inactive Publication Date: 2014-11-19
EXELIXIS INC
View PDF5 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Despite advances in systemic therapy for CRPC, survival improvements have been limited, and virtually all patients die of the disease within ~2 years

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Dual inhibitor of met and vegf for treating cancer
  • Dual inhibitor of met and vegf for treating cancer
  • Dual inhibitor of met and vegf for treating cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0085] In one embodiment, the compound of formula I is a compound of formula Ia:

[0086]

[0087]Formula Ia

[0088] or a pharmaceutically acceptable salt thereof, wherein:

[0089] R 1 is a halo group;

[0090] R 2 is halo; and

[0091] Q is CH or N.

[0092] In another embodiment, the compound of formula I is compound 1:

[0093]

[0094] Compound 1

[0095] or a pharmaceutically acceptable salt thereof. As previously indicated, compound 1 is referred to herein as N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N'-(4- fluorophenyl)cyclopropane-1,1-dicarboxamide. WO2005 / 030140 discloses compound 1 and describes how it is prepared (Example 12, Example 37, Example 38 and Example 48) and also discloses the therapeutic activity of this compound to inhibit, modulate and / or modulate the signal transduction of kinases (assay , Table 4, entry 289). Example 48 is in paragraph [0353] of WO2005 / 030140.

[0096] In other embodiments, the compound of Formula I, Formu...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
Login to view more

Abstract

This invention is directed to the treatment of cancer, particularly castration-resistant prostate cancer and bone metastases, with a dual inhibitor of MET and VEGF.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of priority to US Provisional Application No. 61 / 557,358, filed November 8, 2011, the entire contents of which are incorporated herein by reference. field of invention [0003] The present invention relates to the treatment of cancer, in particular castration-resistant prostate cancer and bone metastases, with dual inhibitors of MET and VEGF. Background of the invention [0004] Castration-resistant prostate cancer (CRPC) is the leading cause of cancer-related death in men. Despite advances in systemic therapy for CRPC, survival improvements have been limited, and virtually all patients succumbed to the disease within about 2 years. The major cause of morbidity and mortality in CRPC is bone metastasis, which occurs in approximately 90% of cases. [0005] Bone metastasis is a complex process involving the interaction between cancer cells and components of the bone microenvironment, ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/47A61K31/517A61P35/00A61K35/04
CPCA61K31/517A61K31/47A61P13/08A61P19/08A61P35/00A61P35/04
Inventor D.T.阿夫塔布F.施莫尔勒
Owner EXELIXIS INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap