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Method Of Quantifying Cancer Treatment

A technology for cancer treatment, cancer, applied in the direction of instruments for radiological diagnosis, computer-aided medical procedures, applications, etc., which can solve the problem of limited survival improvement

Inactive Publication Date: 2014-09-10
EXELIXIS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Despite advances in systemic therapy for CRPC, survival improvements have been limited, and virtually all patients die of the disease within ~2 years

Method used

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  • Method Of Quantifying Cancer Treatment
  • Method Of Quantifying Cancer Treatment
  • Method Of Quantifying Cancer Treatment

Examples

Experimental program
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Effect test

Embodiment approach

[0086] In one embodiment, the compound of formula I is a compound of formula Ia:

[0087]

[0088] or a pharmaceutically acceptable salt thereof, wherein:

[0089] R 1 is a halo group;

[0090] R 2 is halo; and

[0091] Q is CH or N.

[0092] In another embodiment, the compound of formula I is compound 1:

[0093]

[0094] or a pharmaceutically acceptable salt thereof. As previously indicated, compound 1 is referred to herein as N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N'-(4- fluorophenyl)cyclopropane-1,1-dicarboxamide. WO2005 / 030140 discloses compound 1 and describes how it is prepared (Example 12, Example 37, Example 38 and Example 48) and also discloses the therapeutic activity of this compound to inhibit, modulate and / or modulate the signal transduction of kinases (assay , Table 4, entry 289). Example 48 is in paragraph [0353] of WO2005 / 030140.

[0095] In other embodiments, the compound of Formula I, Formula Ia or Compound 1 or a pharmaceutically...

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Abstract

This invention is directed to a method for quantifying cancer treatment response in patients with bone metastases using computer aided bone scan assessment, comprising: (a) obtaining a bone scan image; (b) normalizing the obtained bone scan image to identify normalized bone scan lesions; and (c) quantitatively assessing the normalized bone scan lesions using bone scan lesion area, bone scan intensity, or bone scan lesion count.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of priority to US Provisional Application No. 61 / 557,362, filed November 8, 2011, the entire contents of which are incorporated herein by reference. field of invention [0003] The present invention relates to the treatment of cancer, in particular castration-resistant prostate cancer and bone metastases, with dual inhibitors of MET and VEGF. Background of the invention [0004] Castration-resistant prostate cancer (CRPC) is the leading cause of cancer-related death in men. Despite advances in systemic therapy for CRPC, survival improvements have been limited, and virtually all patients succumbed to the disease within about 2 years. The major cause of morbidity and mortality in CRPC is bone metastasis, which occurs in approximately 90% of cases. [0005] Bone metastasis is a complex process involving the interaction between cancer cells and components of the bone microenvironment, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B6/00A61B6/03A61P35/04A61K31/47
CPCA61B6/505A61B6/032A61K31/47A61B6/5217A61B6/508A61B6/037A61P35/04G16H50/30
Inventor J.霍兰
Owner EXELIXIS INC
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