Kit for evaluating 24-hour urinary sodium value of woman

A 24-hour, kit-based technology, applied in the field of medicine, can solve problems such as cumbersome procedures, long urine collection time, and inconvenient urine sodium intake

Active Publication Date: 2015-04-29
PEOPLES HOSPITAL PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

24-hour urine sodium measurement is the most reliable and accurate method at present, but the 24-hour urine collection time is long and the process is cumbersome, which brings a lot of inconvenience to patients
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Method used

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  • Kit for evaluating 24-hour urinary sodium value of woman
  • Kit for evaluating 24-hour urinary sodium value of woman
  • Kit for evaluating 24-hour urinary sodium value of woman

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1, establishment of the inventive method

[0035] The data come from hypertensive patients hospitalized in the hypertension ward of Peking University People's Hospital from August 2011 to November 2012. Inclusion criteria: ①The diagnosis of hypertension was clear. The diagnostic criteria of hypertension were based on the 2010 Chinese guidelines for the prevention and treatment of hypertension. Hypertension was defined as systolic blood pressure ≥ 140mmHg (1mmHg = 0.133kPa) and (or) diastolic blood pressure ≥ 90mmHg when blood pressure was measured 3 times on different days without using antihypertensive drugs. The patient had a history of hypertension in the past and was currently using antihypertensive drugs. His blood pressure was <140 / 90mHg, and he was also diagnosed as hypertension. ② Stable regular diet in the past 1 month. ③ Fill in the informed consent. Exclusion criteria: ①Hypertension accompanied by severe multi-system diseases (such as rheumatic...

Embodiment 2

[0046] Embodiment 2, verification of the inventive method

[0047] There were 101 female patients in the verification group, and the predicted value of urine sodium (e-24HUNa) for 24 hours was calculated by the Kawasaki method, Tanaka method and SUN1 method respectively, and the accuracy was compared with the predicted value and the measured value (r-24HUNa) , the results are shown in Table 1:

[0048] Table 1 Accuracy comparison of three methods

[0049]

[0050] * P is the chi-square test value compared with the SUN1 method

[0051] It can be seen from Table 1 that compared with the K method, the 30% accuracy and 50% accuracy of the estimation of e-24HUNa by the SUN1 method are significantly improved (P0.05), but the 50% accuracy was significantly improved (P<0.05).

[0052] figure 1 Bland-Altman plot of predicted urinary sodium versus measured urinary sodium for K-method SMU.

[0053] figure 2 Bland-Altman plot of predicted versus measured urinary sodium for T-meth...

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Abstract

The invention provides a kit for evaluating the 24-hour urinary sodium value of a woman. The kit comprises a product for detecting a point urinary sodium value, a product for detecting a point urine creatinine value and a carrier with the following recorded formula: e-24HUNa=0.241*PRCr*(SUNa/SUCr)0.312, wherein PRCr represents for a predicted 24-hour urine creatinine value, and PRCr=e(7.210-0.013*age-0.002*height+0.010*weight); e-24HUNa represents for a predicted 24-hour urinary sodium value; SUNa represents for the point urinary sodium value; SUCr represents for the point urine creatinine value; and SUNa/SUCr represents for the ratio of the point urinary sodium value to the point urine creatinine value. The accuracy of the 24-hour urinary sodium value of the woman, predicted by using the kit provided by the invention, is equivalent to the 24-hour urinary sodium values of the woman, obtained by using the traditional Kawasaki method and the traditional Tanaka method, and the kit has an important role in guiding the lifestyle and drug therapy of a hypertensive patient and helping to judge whether the salt intake of the hypertensive patient exceeds the standard.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a kit for evaluating 24-hour urine sodium value of women. Background technique [0002] High salt is an important environmental factor for the occurrence of hypertension. Most research results have confirmed that high-salt diet is an important risk factor for high blood pressure. By reducing salt intake, the effect of lowering blood pressure is more obvious, especially for those who are sensitive to salt. High salt intake is associated with hypertensive target organ damage such as left ventricular hypertrophy, arteriosclerosis, proteinuria, and the incidence and mortality of cardiovascular and cerebrovascular events. Salt restriction has a protective effect on target organs independent of the antihypertensive effect . Therefore, salt restriction intervention can not only prevent and control hypertension and reduce the incidence of hypertension, but also reduce cardiovascular adverse eve...

Claims

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Application Information

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IPC IPC(8): G01N33/70G01N35/00
CPCG01N33/70
Inventor 王鸿懿韩伟中马志毅孙宁玲张志丽王及华王鲁雁喜杨赵立超陈源源
Owner PEOPLES HOSPITAL PEKING UNIV
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