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Extraction and purification method of gastrodin

A purification method and technology of gastrodin, applied in chemical instruments and methods, organic chemistry, preparation of sugar derivatives, etc., can solve the problems of low yield, complex organic solvent, high cost, etc., and achieve high product yield and short extraction time , the effect of improving the yield rate

Active Publication Date: 2015-05-06
西安崟恒植物制品有限公司
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AI Technical Summary

Problems solved by technology

While the product yield is low, the use of organic solvents is more complicated and costly

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] A method for extracting and purifying gastrodin, comprising the steps in turn:

[0017] (1) Crushing treatment: crush 10kg of dry Gastrodia elata until the particle size passes through a 80-mesh sieve.

[0018] (2) Ultrasonic atomization extraction: Mix the pulverized Gastrodia elata raw material and ethanol at a weight ratio of 1:2, and then perform ultrasonic atomization extraction twice. The extraction conditions are temperature 25°C, frequency 1MHZ, and extraction time 20 minutes. After the extract was concentrated, 4.75 kg of gastrodin extract was obtained. Calculated by raw materials, the extract yield is 47.5%.

[0019] (3) Adsorption and elution on silica gel column: Dissolve gastrodin extract with 0.5 times the weight of ethanol and load it on the silica gel column, elute with 10% ethanol aqueous solution for 3 times the volume of the silica gel column, then change to 50% ethanol aqueous solution for elution, After collecting the eluate and concentrating, 205...

Embodiment 2

[0022] A method for extracting and purifying gastrodin, comprising the steps in turn:

[0023] (1) Crushing treatment: crush 10kg of dry Gastrodia elata until the particle size passes through a 80-mesh sieve.

[0024] (2) Ultrasonic atomization extraction: Mix the pulverized Gastrodia elata raw material and ethanol at a weight ratio of 1:5, and then perform ultrasonic atomization extraction twice. The extraction conditions are temperature 40°C, frequency 2MHZ, and extraction time 40 minutes. After the extract was concentrated, 5.42 kg of gastrodin extract was obtained. Calculated by raw materials, the extract yield is 54.2%.

[0025] (3) Silica gel column adsorption and elution: Dissolve gastrodin extract with 0.5 times the weight of ethanol and load it on a silica gel column, elute with 10% ethanol aqueous solution for 5 times the volume of the silica gel column, then change to 50% ethanol aqueous solution for elution, After collecting and concentrating the eluate, 243 g of...

Embodiment 3

[0028] A method for extracting and purifying gastrodin, comprising the steps in turn:

[0029] (1) Crushing treatment: crush 10kg of dry Gastrodia elata until the particle size passes through a 80-mesh sieve.

[0030] (2) Ultrasonic atomization extraction: Mix the pulverized Gastrodia elata raw material and ethanol at a weight ratio of 1:3, and then perform ultrasonic atomization extraction twice. The extraction conditions are temperature 35°C, frequency 1.4MHZ, and extraction time 25 minutes. After the extract was concentrated, 5.16 kg of gastrodin extract was obtained. Calculated by raw materials, the extract yield is 51.6%.

[0031] (3) Adsorption and elution on silica gel column: Dissolve gastrodin extract with 0.5 times the weight of ethanol and load it on the silica gel column, elute with 10% ethanol aqueous solution for 4 times the volume of the silica gel column, and replace it with 50% ethanol aqueous solution for elution. After collecting the eluate and concentrati...

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Abstract

The invention relates to an extraction and purification method of gastrodin. According to the extraction and purification method, the purified gastrodin can be obtained by virtue of grinding treatment, ultrasonic nebulization extraction, silica gel column adsorption elution and recrystallization. The extraction and purification method is mild in overall process conditions, relatively high in product yield, and advantageous for the practical operations of large-scale production, and conforms to the control requirements of the industrial production.

Description

technical field [0001] The invention relates to a production method of gastrodin, in particular to a separation and purification method for extracting gastrodin from Gastrodia elata. Background technique [0002] Gastrodia elata, as a precious Chinese herbal medicine, has a medicinal history of more than two thousand years in my country. At present, research at home and abroad has found that gastrodin, the main component of Gastrodia elata, can treat pain, dizziness, numbness of limbs, and convulsions. Clinically, it mainly treats arterial Insufficient blood supply, vestibular neuronitis, vertigo, coronary heart disease, etc. [0003] At present, the traditional techniques for extracting gastrodin mainly include alcohol extraction, microwave extraction, ultrasonic extraction, enzyme extraction and supercritical extraction. The common problems in the prior art are mainly that the extraction rate of gastrodin is low, the output content of the product is low, and the process a...

Claims

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Application Information

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IPC IPC(8): C07H15/203C07H1/08
CPCC07H1/08C07H15/203
Inventor 张小燕杨阳朱富荣
Owner 西安崟恒植物制品有限公司
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