Lignans isolated from Acorus calamus, its preparation and application

A technology of lignans and calamus, applied in ether separation/purification, ether preparation, organic chemistry, etc., can solve problems such as undisclosed extracts

Inactive Publication Date: 2016-06-15
TONGJI UNIV
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  • Description
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  • Application Information

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Problems solved by technology

However, the patent does not disclose the specific substance of its extract

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  • Lignans isolated from Acorus calamus, its preparation and application
  • Lignans isolated from Acorus calamus, its preparation and application
  • Lignans isolated from Acorus calamus, its preparation and application

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Embodiment

[0027] 1. The method of extracting and separating tatarinanS-T from the rhizome of Acorus calamus:

[0028] 10 kg of the traditional Chinese medicine Shichangpu was pulverized, extracted twice with 95% ethanol under reflux, combined the two extracts, concentrated under reduced pressure, and dried in vacuum to obtain 700 g of extract. Suspend the extract with about 5 times the amount of water, and extract with petroleum ether, chloroform, and n-butanol in sequence. After recovering the solvent, extracts of various fractions were obtained. Chloroform extraction part (total 190g) was chromatographed on 100-200 mesh silica gel, and petroleum ether-acetone solution with a volume ratio of 5:1 was used as the mobile phase for gradient elution to obtain 6 fractions Fr.1-Fr.6 ; Fr.2 among them was separated and purified by silica gel column, reversed phase column and gel column in turn to obtain the compound tatarinanS-T. Wherein, the silica gel H is used for the silica gel column, a...

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Abstract

The invention relates to two lignans compounds tatarinan S-T separated from rhizoma acori graminei as well as pharmaceutical compositions and application thereof. Experiments prove that the compounds tatarinan S and tatarinan T have remarkable anti-senile dementia activity and can be used for preparing anti-senile dementia drugs.

Description

technical field [0001] The invention relates to lignan compounds, in particular to the lignan compounds separated from calamus calamus, its preparation and application. Background technique [0002] Alzheimer's disease (Alzheimer's disease, AD), also known as Alzheimer's disease, was first reported by Alois Alzheimer in 1907. It is a progressive neurodegenerative disease. The decline of self-care ability eventually leads to progressive cognitive dysfunction and loss, neurobehavioral abnormalities, mental conditions and complete loss of self-care ability. The incidence of AD has an inseparable relationship with human aging. With the aging of the world's population, the incidence of AD is increasing day by day. doubled every year. At present, there are about 36 million AD patients worldwide, and it is expected to increase sharply to 115 million by 2050 (Alzheimer'sdisease International. World Alzheimer Report 2010. London, 2009; DefinaP.A.etal.JournalofAgingResearch, 2013, 1...

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): C07C43/215C07C43/21C07C41/34C07C41/36A61K31/09A61P25/28
CPCA61K31/09C07C41/34C07C41/36C07C2602/08C07C43/215C07C43/21
Inventor王红兵张营营
OwnerTONGJI UNIV