Application of fermented soybean extract in preparation of medicines and health care products for preventing senile dementia related diseases

A technology of soybean extract and senile dementia, which is applied in the field of medicine, can solve the problems of unseen related reports on the application, and achieve the effect of expanding the scope of application and adding new uses

Inactive Publication Date: 2016-11-23
INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There is no relevant report on the application of the fermented soybean extract disclosed in the present invention in the prevention and treatment of senile dementia-related diseases

Method used

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  • Application of fermented soybean extract in preparation of medicines and health care products for preventing senile dementia related diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1, the preparation of fermented soybean extract

[0015] ①Put 300g of soybean miso in a blast drying oven to dry to a moisture content of 8%, and then crush the soybean miso powder with a grinder to pass through a 20-mesh sieve.

[0016] ② Put 100g of soybean miso powder obtained in step ① into CO 2 In a supercritical extractor, the extraction temperature is 55° C., the extraction pressure is 35 MPa, and the extraction time is 0.5 h, to prepare 13 g of fermented soybean extract.

[0017] ③ HPLC-APCI / MS analysis confirmed that the fermented soybean extract prepared by this method was mainly glyceride components, and the content of glyceride components was determined to be 80% by GC, detected by HPLC-ELSD, and the area normalization method was used to determine the diglyceride components The content is 18%.

Embodiment 2

[0018] Embodiment 2, the preparation of fermented soybean extract

[0019] ①Put 300g of soybean miso in a blast drying oven and dry to a moisture content of 11%, then crush the soybean miso powder with a grinder to pass through a 20-mesh sieve.

[0020] ② Place 100 g of soybean miso powder obtained in step ① in supercritical CO 2 In the extractor, the extraction temperature was 35° C., the extraction pressure was 25 MPa, and the extraction time was 1.5 h, to prepare 14 g of fermented soybean extract.

[0021] ③ HPLC-APCI / MS analysis confirmed that the fermented soybean extract prepared by this method is mainly glyceride components, GC determined that the content of glyceride components was 85%, HPLC-ELSD detection, area normalization method to determine diglyceride components The content is 12%.

Embodiment 3

[0022] Embodiment 3, the preparation of fermented soybean extract

[0023] ①Put 300g of soybean miso in a blast drying oven and dry to a moisture content of 15%, then crush the soybean miso powder with a grinder to pass through a 20-mesh sieve.

[0024] ② Place 100 g of soybean miso powder obtained in step ① in supercritical CO 2 In the extractor, the extraction temperature is 45° C., the extraction pressure is 30 MPa, and the extraction time is 1 h, to prepare 15 g of fermented soybean extract.

[0025] ③ HPLC-APCI / MS analysis confirmed that the fermented soybean extract prepared by this method was mainly glyceride components, and the content of glyceride components was determined to be 75% by GC, detected by HPLC-ELSD, and the area normalization method was used to determine the diglyceride components The content is 15%.

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Abstract

The invention provides application of fermented soybean extract in preparation of medicines and health care products for preventing senile dementia related diseases. The fermented soybean extract comprises components such as glyceride with the content of 70% or higher. The invention provides novel application of fermented soybean extract, application with patent application number of 201510007348.8 for using the fermented soybean extract for preventing and treating radiation damage related diseases is widened to the conventional application of preventing and treating senile dementia related diseases, and the application range is widened. The experiments prove that the fermented soybean extract disclosed by the invention has the effect of resisting senile dementia on a transgenic caenorhabditis elegans model, and can be used for preparing medicines and health care products capable of resisting senile dementia.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of fermented soybean extracts in the preparation of medicines and health care products for preventing and treating diseases related to senile dementia. Background technique [0002] Senile dementia refers to various dementia syndromes that occur in old age, including Alzheimer's disease (AD), vascular dementia (VD), mixed dementia and other dementias. The first two are Its main type accounts for 90% of all dementias. By the end of 2013, there were more than 44 million dementia patients worldwide, and it is expected to exceed 135 million by 2050, of which 62% are in developing countries. my country has entered an aging society, and it is estimated that the number of patients will exceed 20 million by 2050, making it the region with the largest population of AD patients and the fastest growing rate in the world. The World Health Organization and the Alzheimer's A...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P25/28A23L1/29
Inventor 董俊兴田瑛何轩辉刘士军陈恒文李彬汪琼陈立
Owner INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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