Method for treating lung cancer by improving autogenous DC-CIK immunocytes

A DC-CIK, immune cell therapy technology, applied in the direction of mammalian medical raw materials, drug combinations, anti-tumor drugs, etc., can solve problems such as high cost and poor effect, achieve broad market prospects, and improve the effect of recovery probability.

Inactive Publication Date: 2015-06-24
ZHOUSHAN HOSPITAL
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] The problem to be solved by the present invention is that the existing

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0042] The present invention will be further described below in conjunction with embodiment.

[0043] A method for improving autologous DC-CIK immune cells to treat lung cancer, comprising the following steps:

[0044] A. Patient selection, inclusion criteria for lung cancer patients: age ≤ 75 years old; Karnofsky score > 60; expected survival > 6 months, exclusion criteria: 1. Pregnant or lactating women 2. Organ failure; 3. Organs Transplant recipients; 4. Patients with severe autoimmune diseases; 5. Uncontrollable infectious diseases; 6. Those who are allergic to biological agents used in treatment; 7. T-cell lymphoma; 8. Those who hinder the signing and understanding of informed consent;

[0045] B. Examination and evaluation before treatment, enhanced chest CT; routine blood test (WBC>3.0×10*9 / L, LC>15%; Hb>80g / L; PLT>60×10*9 / L), liver and kidney Function, PT (prolongation <50%), T lymphocyte subsets, tumor markers, detection of SCC (squamous cell carcinoma); hepatitis B...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides a method for treating lung cancer by improving autogenous DC-CIK immunocytes. The method comprises the following steps: selecting patients according to a lung cancer patient inclusion criteria that the age is less than or equal to 75 years, the Karnofsky score is more than 60 and the estimated lifetime is more than 6 months; performing inspection and evaluation before treatment, namely performing chest CT (computed tomography) enhancement, performing blood routine examination, detecting liver and kidney functions, detecting the PT (prothrombin time) (prolonging for less than 50%), detecting T lymphocyte subsets and tumor markers, detecting SCC (squamous cell carcinoma), and detecting three systems of hepatitis B (negative surface antigen), negative hepatitis C antibody, negative HIV antibody and negative syphilis antibody; after determination, sending an application form to a biological treatment center; performing pure autogenous immunocyte treatment, sampling 75ml of blood, performing cell culture for 11 days or sampling 75ml of blood on the day before GP chemotherapy/radiotherapy and autogenous immunocyte treatment chemotherapy, and performing cell culture for 11 days; and performing quality detection on the cultured cells on the eleventh day and the thirteenth day.

Description

technical field [0001] The invention relates to a method for improving autologous DC-CIK immune cells to treat lung cancer, belonging to the field of lung cancer treatment. Background technique [0002] Lung cancer does not have any special symptoms in the early stage, only common symptoms of general respiratory diseases, such as cough, bloody sputum, low-grade fever, chest pain, shortness of breath, etc., which are easy to ignore. [0003] Specific manifestations of common early symptoms of lung cancer: [0004] 1. Cough Lung cancer usually produces respiratory tract irritation symptoms and irritating cough because it grows on the bronchopulmonary tissue; [0005] 2. Low-grade fever. After the tumor blocks the bronchi, obstructive lung lobes often exist, with varying degrees. Mild cases only have low-grade fever, while severe cases have high fever. After taking medicine, it can temporarily improve, but it will relapse soon; [0006] 3. Chest pain In the early stage of lun...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K35/14A61K35/15A61P35/00
Inventor 张永奎乐涵波续力云陈志军刘晓光
Owner ZHOUSHAN HOSPITAL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap