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An animal dorsal root ganglion-spinal cord fixed imaging and compression injury combination device

A dorsal root ganglion and combined device technology, which is applied in medical science, veterinary equipment, musculoskeletal system assessment, etc., can solve the problems of injury modeling, failure to complete, and inability to observe the dorsal root ganglion

Inactive Publication Date: 2017-04-12
GENERAL HOSPITAL OF PLA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, it only provides a fixed observation device for the spinal cord, and cannot observe the dorsal root ganglia, let alone complete functions such as injection, imaging, and injury modeling.

Method used

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  • An animal dorsal root ganglion-spinal cord fixed imaging and compression injury combination device
  • An animal dorsal root ganglion-spinal cord fixed imaging and compression injury combination device
  • An animal dorsal root ganglion-spinal cord fixed imaging and compression injury combination device

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Embodiment Construction

[0035] Specific see Figure 1-11 The combined device of the present invention includes a dorsal root ganglion-spinal cord fixation imaging device 1, and an integrated device 2 for microscopic fluorescent dye injection and spinal cord compression injury. The dorsal root ganglion-spinal cord fixation imaging device achieves clamp fixation of single or multiple segments of the animal spine by adjusting the horizontal slider 1-2-1 and the L-shaped sliding rod fixation block 1-2-2, Then perform single-stage or multi-stage laminectomy and pedicle resection, and lift the lateral sliding clip 1-4-1 of the spine fixation clip 1-4 to rotate the spine in the medial direction to expose the lateral dorsal root ganglia. Purpose, after the operation, the microinjector 2-5-1 connected to the air pump connector 2-5-2 through the computer controlled air pump device was used to microinject the adeno-associated virus-green fluorescent protein and other dyes into the dorsal root ganglia. After the ...

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Abstract

The invention relates to an animal dorsal root ganglion-spinal cord fixed imaging and compression injury combining device, which comprises a dorsal root ganglion-spinal cord fixed imaging device and a microscopic fluorescent dye injection and spinal cord compression injury integrating device, wherein the animal dorsal root ganglion-spinal cord fixed imaging device (1) comprises a horizontal slide block guide rail (1-1), a fixing component (1-2), a slide rod (1-3) and a spine fixing clamp (1-4), and the microscopic fluorescent dye injection and spinal cord compression injury integrating device (2) comprises a vertical-rotating regulating side rod (2-3), a horizontal regulating component (2-4), a microscopic injection component (2-5) and a spinal cord compression component (2-6). The combining device has the advantages that multiple functions are integrated, the operation is simple and convenient, the switching can be realized at any time, different-degree spinal cord injury animal models can be conveniently manufactured, and after the fluorescent dye microscopic injection, a two-photon microscope is used for dynamically observing the pathological and physiological change process of the dorsal root ganglion-spinal cord injury in real time.

Description

Technical field [0001] The invention discloses an animal dorsal root ganglion-spinal cord fixed imaging and compression injury device, which is mostly used in experimental research in the field of neurobiology. The device of the present invention can perform two-photon dynamic imaging of neurons and nerve fibers on single or multiple dorsal root ganglia and spinal cord segments of animals; and can form animal models of compressive spinal cord injury in different degrees. The device of the present invention has great value for studying the pathophysiological changes of dorsal root ganglia and spinal cord injury, and for establishing an animal model of spinal cord compression injury. Background technique [0002] In experimental research in the field of neurobiology, the traditional imaging method of dorsal root ganglia and spinal cord is to do tissue sectioning. This technique requires killing the animal and removing the tissue. After fixing the dorsal root ganglion and spinal cor...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/00A61D1/00
CPCA61B5/0059A61B5/45A61B2503/40A61D1/00A61D7/00
Inventor 张逸凌唐佩福张立海季欣然
Owner GENERAL HOSPITAL OF PLA
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