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Preparation method and application of osteoproliferation removal tablets

A technology of Rhizoma Drynariae and Caulis Spatholobus, applied in the field of preparation of Guzengxiao Tablets, can solve the problems of rough process, affecting application, and many impurities

Pending Publication Date: 2015-09-30
JILIN ZHENGHE PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of cationic resin and supercritical technology in the extraction and preparation of Guzengxiao Tablets. However, the method of crushing and decocting in water is rough and backward in process and has many impurities, which leads to excessive dosage for patients and unnecessary It is convenient to take, which seriously affects the clinical application of this product

Method used

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  • Preparation method and application of osteoproliferation removal tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: get Rehmannia glutinosa 208g, Caulis Spatholobus 140g, Epimedium 140g, Drynaria fortunei 140g, Dog spine 140g, Laifuzi 70g, Lycium barbarum 70g, Cynomorium 140g, intermittent 70g, pulverize, add 20, 16. Decoct and extract 14 times the amount of water three times, each time for 1 hour, combine the three extracts, filter, remove the slag and take the liquid, concentrate to 65 °C when the relative density is 1.10, add ethanol to make the volume percentage of the alcohol content reach 50% , precipitate, stand still, and filter to obtain the alcohol precipitation solution; the alcohol precipitation solution is adsorbed by 10kg cation exchange resin 001×7, the flow rate of the sample is 2ml / min, and the effluent is used for standby, and 10L 0.5mol / L ammonia water is used for the cation exchange resin Perform elution, collect the eluent, combine the effluent and ammonia eluent after cation exchange resin adsorption, reclaim ethanol, join in CO2 supercritical extra...

Embodiment 2

[0016] Embodiment 2: get Rehmannia glutinosa 208g, Caulis Spatholobus 140g, Epimedium 140g, Drynaria fortunei 140g, Dog spine 140g, Laifuzi 70g, Lycium barbarum 70g, Cynomorium 140g, intermittent 70g, pulverize, add 20, 16. Decoct and extract 14 times the amount of water three times, each time for 1 hour, combine the three extracts, filter, remove the slag and take the liquid, concentrate to 65 °C when the relative density is 1.10, add ethanol to make the volume percentage of the alcohol content reach 50% , precipitate, stand still, and filter to obtain the alcohol precipitation solution; the alcohol precipitation solution is adsorbed by 10kg cation exchange resin 001×7, the flow rate of the sample is 2ml / min, and the effluent is used for standby, and 10L 0.5mol / L ammonia water is used for the cation exchange resin Perform elution, collect the eluent, combine the effluent and ammonia eluent after cation exchange resin adsorption, reclaim ethanol, join in CO2 supercritical extra...

Embodiment 3

[0017] Embodiment 3: get Rehmannia glutinosa 208g, Caulis Spatholobus 140g, Epimedium 140g, Drynaria fortunei 140g, Dog spine 140g, Laifuzi 70g, Lycium barbarum 70g, Cynomorium 140g, intermittent 70g, pulverize, add 20, 16. Decoct and extract 14 times the amount of water three times, each time for 1 hour, combine the three extracts, filter, remove the slag and take the liquid, concentrate to 65 °C when the relative density is 1.10, add ethanol to make the volume percentage of the alcohol content reach 50% , precipitate, stand still, and filter to obtain the alcohol precipitation solution; the alcohol precipitation solution is adsorbed by 10kg cation exchange resin 001×7, the flow rate of the sample is 2ml / min, and the effluent is used for standby, and 10L 0.5mol / L ammonia water is used for the cation exchange resin Perform elution, collect the eluent, combine the effluent and ammonia eluent after cation exchange resin adsorption, reclaim ethanol, join in CO2 supercritical extra...

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Abstract

The invention belongs to the field of traditional Chinese medicine preparations, and particularly provides a preparation method of osteoproliferation removal tablets. The osteoproliferation removal tablets comprise the active pharmaceutical ingredients of 208 g of prepared rehmannia roots, 140 g of caulis spatholobi, 140 g of herba epimedii, 140 g of rhizoma drynariae, 140 g of rhizoma cibotii, 70 g of semen raphani, 70 g of wolfberry fruits, 140 g of cynomorium songaricum and 70 g of himalayan teasel roots. The osteoproliferation removal tablets are prepared from cationic resin in a supercritical extraction mode, the content is greatly increased, and the dosage is decreased. The invention further provides the application of the osteoproliferation removal tablets in preparing medicine for restraining proliferation of human tissue cell lymphoma U937 cells.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Guzengxiao tablets. Background technique [0002] Guzengxiao Tablets are recorded in the standard of the Ministry of Health, consisting of Rehmannia glutinosa 208g, Caulis Spatholobus 140g, Epimedium 140g, Drynaria fortunei 140g, Dogji 140g, Laifuzi 70g, Lycium barbarum 70g, Cynomorium 140g, and intermittent 70g. Made from raw materials, the above nine flavors, dog spines and epimedium are crushed into fine powder, and the remaining seven flavors such as Rehmannia glutinosa are decocted twice, each time for 1.5 hours, filtered in several times, and the filtrates are combined and concentrated under reduced pressure to relative The thick paste with a density of 1.3-1.35 is mixed with the above-mentioned fine powder, dried, pulverized, made into granules, dried, pressed into tablets, coated with sugar or film,...

Claims

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Application Information

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IPC IPC(8): A61K36/815A61K9/20A61P35/00
Inventor 孟令旭姜华姜珂
Owner JILIN ZHENGHE PHARMA GRP
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