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Application of butylphthalide and its derivatives in preparation of medicines for treating or preventing cerebral concussion

A technology of butylphthalide and derivatives, applied in the field of pharmaceutical use

Active Publication Date: 2016-03-23
SHIJIAZHUANG PHARMA GRP NBP PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research on butylphthalide in the treatment of concussion has not been reported at home and abroad.

Method used

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  • Application of butylphthalide and its derivatives in preparation of medicines for treating or preventing cerebral concussion
  • Application of butylphthalide and its derivatives in preparation of medicines for treating or preventing cerebral concussion
  • Application of butylphthalide and its derivatives in preparation of medicines for treating or preventing cerebral concussion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] Embodiment 1: the preparation of the butylphthalide composition of titanium dioxide nanometerization

[0080] (1) Dissolve 38.54g of hydroxypropyl-β-cyclodextrin (0.025mol) in 150g of water, add 1.0g of butylphthalide; stir and dissolve until the solution is clear;

[0081] (2) Add 3.2 g of titanium dioxide nanotubes (average tube diameter 51 nm, average tube length 132 nm) into the solution described in step (1), ultrasonically disperse for 60 minutes, and load butylphthalide into the titanium dioxide nanotubes;

[0082] (3) The solution obtained in step (2) is freeze-dried to obtain a titanium dioxide nano-sized butylphthalide composition.

Embodiment 2

[0083] Embodiment 2: the preparation of the butylphthalide composition of titanium dioxide nanometerization

[0084] (1) Dissolve 4.5g of polyethylene glycol-12-hydroxystearate in 400g of water, add 1.0g of butylphthalide; stir and dissolve until the solution is clear;

[0085] (2) Add 4.5 g of titanium dioxide nanotubes (average tube diameter 70 nm, average tube length 148 nm) into the solution described in step (1), ultrasonically disperse for 100 min, and load butylphthalide into the titanium dioxide nanotubes;

[0086] (3) The solution obtained in step (2) is freeze-dried to obtain a titanium dioxide nano-sized butylphthalide composition.

Embodiment 3

[0087] Embodiment 3: the preparation of the butylphthalide composition of titanium dioxide nanometerization

[0088] (1) Dissolve 32.38g of hydroxypropyl-β-cyclodextrin (0.021mol) in 120g of water, add 1.0g of butylphthalide; stir and dissolve until the solution is clear;

[0089] (2) Add 2.8 g of titanium dioxide nanotubes (average tube diameter 42 nm, average tube length 115 nm) into the solution described in step (1), ultrasonically disperse for 45 minutes, and load butylphthalide into the titanium dioxide nanotubes;

[0090] (3) The solution obtained in step (2) is freeze-dried to obtain a titanium dioxide nano-sized butylphthalide composition.

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PUM

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Abstract

On one aspect, the invention provides new application of butylphthalide and relates to application of the butylphthalide and its derivatives in preparation of medicines for treating or preventing cerebral concussion caused by accidents.

Description

technical field [0001] The invention relates to the field of medicine use, in particular to the use of butylphthalide or its derivatives in the preparation of medicines for treating or preventing concussions caused by accidents. Background technique [0002] A concussion is a short-term brain dysfunction immediately after the head is hit by an external force. There is no significant change in the pathological changes, and the mechanism of occurrence is still controversial. The clinical manifestations were transient coma, amnesia of recent events, headache, nausea and vomiting, and no positive signs were found in neurological examination. [0003] Most concussions show transient changes in neurological function, but without timely and effective treatment, repeated and long-term concussions, the pathological changes in brain tissue are particularly significant, which can cause serious sequelae, and there are some cases of death due to concussions. Cases and boxers suffer fro...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61K31/192A61K47/02A61P25/00
Inventor 牛锋黄慭齐军彩王丹焦魁良
Owner SHIJIAZHUANG PHARMA GRP NBP PHARMA CO LTD
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