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Application of butylphthalide or its derivatives in the preparation of medicines for treating or preventing concussion

A technology of butylphthalide and concussion, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc.

Active Publication Date: 2019-08-16
SHIJIAZHUANG PHARMA GRP NBP PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research on butylphthalide in the treatment of concussion has not been reported at home and abroad.

Method used

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  • Application of butylphthalide or its derivatives in the preparation of medicines for treating or preventing concussion
  • Application of butylphthalide or its derivatives in the preparation of medicines for treating or preventing concussion
  • Application of butylphthalide or its derivatives in the preparation of medicines for treating or preventing concussion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Embodiment 1: the preparation of the butylphthalide composition of titanium dioxide nanometerization

[0078] (1) Dissolve 38.54g of hydroxypropyl-β-cyclodextrin (0.025mol) in 150g of water, add 1.0g of butylphthalide; stir and dissolve until the solution is clear;

[0079] (2) 3.2 g of titanium dioxide nanotubes (average diameter 51 nm, average tube length 132 nm) were added to the solution described in step (1), ultrasonically dispersed for 60 min, and butylphthalide was loaded in the titanium dioxide nanotubes;

[0080] (3) Freeze-drying the solution obtained in step (2) to obtain a titanium dioxide nano-sized butylphthalide composition.

Embodiment 2

[0081] Embodiment 2: the preparation of the butylphthalide composition of titanium dioxide nanometerization

[0082] (1) Dissolve 4.5g of polyethylene glycol-12-hydroxystearate in 400g of water, add 1.0g of butylphthalide; stir and dissolve until the solution is clear;

[0083] (2) Add 4.5g of titanium dioxide nanotubes (average tube diameter 70nm, average tube length 148nm) into the solution described in step (1), ultrasonically disperse for 100min, and load butylphthalide in the titanium dioxide nanotubes;

[0084] (3) Freeze-drying the solution obtained in step (2) to obtain a titanium dioxide nano-sized butylphthalide composition.

Embodiment 3

[0085] Embodiment 3: the preparation of the butylphthalide composition of titanium dioxide nanometerization

[0086] (1) Dissolve 32.38g of hydroxypropyl-β-cyclodextrin (0.021mol) in 120g of water, add 1.0g of butylphthalide; stir and dissolve until the solution is clear;

[0087] (2) 2.8g of titanium dioxide nanotubes (average tube diameter 42nm, average tube length 115nm) are added in the solution described in step (1), ultrasonically dispersed for 45min, and butylphthalide is loaded in the titanium dioxide nanotubes;

[0088] (3) Freeze-drying the solution obtained in step (2) to obtain a titanium dioxide nano-sized butylphthalide composition.

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Abstract

One aspect of the present invention provides a new use of butylphthalide, which relates to the use of butylphthalide or its derivatives in the preparation of medicines for treating or preventing concussions caused by accidents.

Description

technical field [0001] The invention relates to the field of medicine use, in particular to the use of butylphthalide or its derivatives in the preparation of medicines for treating or preventing concussions caused by accidents. Background technique [0002] A concussion is a short-term brain dysfunction immediately after the head is hit by an external force. There is no significant change in the pathological changes, and the mechanism of occurrence is still controversial. The clinical manifestations were transient coma, amnesia of recent events, headache, nausea and vomiting, and no positive signs were found in neurological examination. [0003] Most concussions show transient changes in neurological function, but without timely and effective treatment, repeated and long-term concussions, the pathological changes in brain tissue are particularly significant, which can cause serious sequelae, and there are some cases of death due to concussions. Cases and boxers suffer fro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/365A61K31/192A61K47/02A61P25/00
Inventor 牛锋黄慭齐军彩王丹焦魁良
Owner SHIJIAZHUANG PHARMA GRP NBP PHARMA CO LTD
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