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Cell penetrating peptide introduced drug-delivery carrier comprising macromolecule

A technology that penetrates peptides and macromolecules, and is used in drug delivery, medical preparations containing active ingredients, and medical preparations without active ingredients.

Active Publication Date: 2016-04-27
AMOREPACIFIC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, there are still many obstacles to using them to treat and prevent diseases

Method used

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  • Cell penetrating peptide introduced drug-delivery carrier comprising macromolecule
  • Cell penetrating peptide introduced drug-delivery carrier comprising macromolecule
  • Cell penetrating peptide introduced drug-delivery carrier comprising macromolecule

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0146] 【Preparation of mixture with o / w nanoemulsion】

[0147] In order to compare the skin absorption and particle size of drug delivery vehicles with or without amphiphilic polymers after mixing the o / w nanoemulsion, by combining the drug delivery vehicles of Example 5 and Example 6 with the o / w nanoemulsion Examples 7 and 8 were prepared as test samples by mixing.

[0148] Specifically, the aqueous and oil phases were prepared as described in Table 2.

[0149] Table 2

[0150]

[0151] The water and oil phases of the above composition were heated to 70°C, respectively. Then, emulsification (homogeneous mixing) was carried out at 7,000 rpm for 3 min with an emulsification homogenizer (T.K. Homomixer Mark II, Takushu Kika Kogyo Ltd., Japan), while the oil phase was slowly added to the water phase. The resulting o / w emulsion was further processed for 3 cycles at 1000 bar using a high pressure emulsifier (Microfluidics Corp., USA) to obtain a nanoemulsion with an average ...

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Abstract

The present disclosure relates to a drug delivery carrier containing a lipid structure or a polymer particle which is covalently bonded to a cell-penetrating AP-GRR peptide (SEQ ID NO 1) or is modified with the peptide chain containing the peptide. The present disclosure also relates to a composition containing the drug delivery carrier and a physiologically active ingredient encapsulated in the carrier. The drug delivery carrier of the present disclosure can effectively deliver macromolecules that are difficult to be delivered into cells, thereby improving the bioavailability of the macromolecules.

Description

[0001] Cross References to Related Applications [0002] This application claims the priority of Korean Application No. 10-2014-0139024 filed on October 15, 2015, and Korean Application No. 10-2015-0130127 filed on September 15, 2015, and is based on 35 U.S.C. §119 requires all benefits resulting therefrom, the entire contents of which are hereby incorporated by reference. technical field [0003] The present invention relates to drug delivery carriers containing macromolecules and incorporating cell-penetrating peptides. Background technique [0004] In general, hydrophilic and bulky substances cannot penetrate cells through the cell membrane barrier. Cell membranes prevent macromolecules such as peptides, proteins, and nucleic acids from entering the cell. Even when they enter the cell through a physiological mechanism called endocytosis of membrane receptors, they are degraded after fusion with the lysosomal cavity. Therefore, there are still many obstacles to using th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/42A61K47/34A61K45/00A61K8/84A61K8/81A61Q19/00A61Q19/10A61Q1/12
CPCA61K8/0241A61K8/042A61K8/062A61K8/14A61K8/64A61K9/0014A61K9/1075A61K9/1271A61K9/1275A61K2800/654A61Q1/02A61Q19/00A61Q19/10A61K47/62A61K47/6911
Inventor 林亨峻朴录贤崔尤利裴日弘高明辰俞载元申松锡李存恒
Owner AMOREPACIFIC CORP
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