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Modeling method of cellular gene translation process

A technology of translation process and modeling method, which is applied in the fields of bioinformatics and computer virtual reality, can solve problems such as differences in the degree of modeling refinement, and achieve the effect of reliable performance

Inactive Publication Date: 2018-07-31
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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Problems solved by technology

Different modeling methods may choose different degrees of abstraction, and the degree of modeling refinement varies

Method used

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  • Modeling method of cellular gene translation process
  • Modeling method of cellular gene translation process
  • Modeling method of cellular gene translation process

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Embodiment Construction

[0043] The present invention will be further described in detail below in conjunction with the examples.

[0044] The invention comprises the following steps: the abstraction of the biological process of gene translation; the mathematical modeling of related biological problems; and the fitting of biochemical reaction parameters with experimental data for related models.

[0045] According to the abstraction of the biological process of gene expression, several key reaction steps of gene expression are obtained. The process of ribosomal translation of mRNA is divided into three steps: initialization, extension, and termination, among which the initialization process has been simplified a lot. The whole process is marked by the state position of the ribosome. For example, the initialization process means that the ribosome is bound to the start site of the mRNA by discrete size subunits; at this time, the position mark of the ribosome becomes By analogy, when extending to site...

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Abstract

The present invention relates to a modeling method of cellular gene translation process, comprising the following steps: according to tracking the state of each mRNA molecule and updating the count in real time, obtaining the quantity that can be initialized in various mRNAs; according to tracking the state of each ribosome molecule and updating the count in real time Update the count to get the number of ribosomes that can move on various mRNA sites; calculate the total initialization speed of the mRNA molecule; calculate the total extension speed of the ribosome molecule on the corresponding mRNA; get the mRNA initialization according to the total initialization speed and the total extension speed and the total probability of ribosome extension; according to the weight of the event probability, an event is randomly selected to react; after the reaction, the cell state is updated; the present invention adopts the principle based on a completely asymmetric simple repulsion process, and considers the half-life of the molecule at the same time. Correct translation takes into account the possibility of wrong translation, making the translation process closer to the essence of biological problems.

Description

technical field [0001] The invention relates to a method for modeling a gene translation process, which belongs to biological information technology, calculation method and computer virtual reality technology. Background technique [0002] Many basic life phenomena such as cell metabolism, growth and differentiation are regulated by intracellular genes, and the regulation of genes is realized through their corresponding protein products. As one of the most basic and critical reactions in cells, more and more experimental evidence shows that protein translation plays a key regulatory role in the normal function of genes in cells. The translation of proteins in cells is generally divided into three main steps: initiation, elongation and termination. The key substance responsible for gene translation is the ribosome: [0003] Ribosomes are composed of two subunits, one large and one small, each of which has a special structure for molecules such as peptide chains, mRNA, tRNA ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G06F19/12
Inventor 李国辉张鼎林
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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