The invention relates to a manufacturing method for a multilayer-uneven-structure brain hematoma model, and belongs to the technical field of biomedicine. The manufacturing method includes the following steps that S1, human-body brain data is scanned through nuclear magnetic resonance to obtain three-dimensional structure data of the skull surface, three-dimensional structure data of the grey matter surface and three-dimensional structure data of the white matter surface; S2, the three-dimensional data of the skull, the three-dimensional data of the grey matter and the three-dimensional data of the white matter are led into 3dsmax to be merged, subjected to model detail reducing and shell adding treating; S3, the model is manufactured according to the data obtained in the S2; S4, cavities corresponding to tissue are filled with corresponding simulation materials, namely, materials with the dielectric constant and the electric conductivity equal to corresponding tissue, and manufacturing of the model is completed; S5, a small rubber bag is arranged in the model, an injector is connected with the small rubber bag arranged in the brain model through a plastic conduit, and the volume of blood in the rubber bag is adjusted to simulate variation of hematoma. According to the manufacturing method, manufacturing is convenient, the result of electromagnetic waves passing through the multilayer-uneven-structure brain can be really responded, the actual condition of brain hematoma can be really simulated, and the manufacturing method can be used in the brain hematoma monitoring technology based on electromagnetism.