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Orai1 gene polymorphism associated with susceptibility to chronic urticaria and its detection preparation

A gene polymorphism, chronic urticaria technology, applied in the fields of molecular biology and medicine, can solve the problem of chronic urticaria susceptibility correlation without research reports

Active Publication Date: 2019-10-22
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Abstract
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Problems solved by technology

However, no studies have reported the correlation between the ORAI1 gene and the susceptibility to chronic urticaria and the efficacy of second-generation antihistamines in the treatment of chronic urticaria

Method used

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  • Orai1 gene polymorphism associated with susceptibility to chronic urticaria and its detection preparation
  • Orai1 gene polymorphism associated with susceptibility to chronic urticaria and its detection preparation
  • Orai1 gene polymorphism associated with susceptibility to chronic urticaria and its detection preparation

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Embodiment Construction

[0036] The following in conjunction with specific embodiments is intended to further illustrate the present invention, rather than limit the present invention.

[0037]1. Patients with chronic spontaneous urticaria were enrolled in strict accordance with the international diagnostic criteria, and randomly administered. At the same time, 3ml of peripheral blood was collected from the patients after signing the informed consent form, and the whole genome DNA was extracted for flight mass spectrometry chip technology to detect SNP. . After the results were reported, bioinformatics analysis was carried out, combined with the single SNP site typing data of the southern Chinese population in the Thousand Genomes Project as the normal control (http: / / browser.1000genomes.org / index.html), after statistical analysis, it was found that rs12313273T / C, rs12320939G / T, rs3741596A / G, rs3741595C / T are associated with susceptibility to chronic spontaneous urticaria; 266 normal people were colle...

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Abstract

The invention provides a single nucleotide polymorphism site of ORAI1 genes of chronic urticaria susceptible patients and a detection agent thereof, and particularly provides a single nucleotide polymorphism site of rs3741595C / T, rs3741596A / G, rs12313273T / C and rs12320930G / T of ORAI1 genes, and the single nucleotide polymorphism site is adopted to detect chronic urticaria and to serve as the drug target for treating chronic urticaria patients. Drugs are applied on this basis, so the efficiency of disease treatment is improved and the living quality of the patients is improved. In addition, the morbidity can be predicted.

Description

technical field [0001] The invention belongs to the fields of molecular biology and medicine. Single nucleotide polymorphism sites involving human ORAI1 gene associated with susceptibility to chronic urticaria and uses thereof. It specifically relates to the polymorphic sites of human ORAI1 gene and the susceptibility to chronic urticaria and the efficacy of second-generation antihistamines in the treatment of chronic urticaria. The invention also relates to agents for detecting these polymorphic sites. Background technique [0002] Chronic urticaria is a common immune skin disease characterized by wheals accompanied by varying degrees of itching. The course of the disease is more than 6 weeks, and 11%-14% can last for more than 5 years. Long-term medication intervention is required. Chronic urticaria also reduces learning and work efficiency to varying degrees, affecting the quality of life of patients. Chronic urticaria is also a polygenic genetic disease, some patients...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883C12N15/11
Inventor 李捷陈翔闫思聿陈旺青郭爱元粟娟朱武
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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