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Colon cancer prognosis prediction marker and detection method thereof

A detection method and marker technology, applied in the field of predictive markers, can solve the problems of low specificity and lack of colon cancer prognostic markers

Active Publication Date: 2016-11-23
SHENZHEN UNIV
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Problems solved by technology

[0006] In view of the above-mentioned deficiencies in the prior art, the purpose of the present invention is to provide a colon cancer prognostic marker and its detection method, aiming to solve the problems of lack of colon cancer prognostic markers and low specificity in the prior art

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  • Colon cancer prognosis prediction marker and detection method thereof
  • Colon cancer prognosis prediction marker and detection method thereof
  • Colon cancer prognosis prediction marker and detection method thereof

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Embodiment Construction

[0024] The present invention provides a colon cancer prognosis predictive marker and a detection method thereof. In order to make the purpose, technical solution and effect of the present invention clearer and clearer, the present invention will be further described in detail below. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0025] The prognosis diagnosis of colon cancer in the present invention refers to predicting or judging the survival period of colon cancer patients, wherein the colon cancer patients are patients after tumor resection.

[0026] The present invention provides a colon cancer prognosis prediction marker, wherein the colon cancer prognosis prediction marker is PBRM1 protein. The PBRM1 protein of the present invention is abnormally expressed in colon cancer clinicopathological samples, and its expression level is significantly correlated with the pat...

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Abstract

The invention discloses a colon cancer prognosis prediction marker and a detection method thereof. The colon cancer prognosis prediction marker is PBRM1 protein. According to the invention, the PBRM1 protein can effectively distinguish the postoperative lifetime of a colon cancer patient, thus a new way is provided for the colon cancer prognosis diagnosis, and a reference basis is provided for a clinical doctor to analyze the colon cancer state. According to the invention, the sample tissue is subjected to immunohistochemical determination; if the dyeing index of the sample tissue is greater than or equal to 6, high expression of PBRM1 protein is judged, which indicates long postoperative lifetime of the colon cancer patient; and if the dyeing index of the sample tissue is less than 6, low expression of PBRM1 protein is judged, which indicates short postoperative lifetime of the colon cancer patient.

Description

technical field [0001] The invention relates to the technical field of predictive markers, in particular to a colon cancer prognosis predictive marker and a detection method thereof. Background technique [0002] Colon cancer is one of the most common malignant tumors. In the world, the incidence of the disease ranks third in men, and the death rate ranks fourth. It ranks second in the incidence of diseases in women, and the death rate reaches the third. . The occurrence of colon cancer begins with abnormal biological, physical, chemical or other environmental factors in colonic tissue cells to produce abnormal lesions and eventually cancerous changes. In the past few decades, the incidence of colon cancer in many countries or regions has been increasing year by year. At present, the treatment for colon cancer is mainly based on surgery, combined with radiotherapy and chemotherapy as supplementary comprehensive treatment methods. However, the prognosis of colon cancer is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574C07K14/47
CPCG01N33/57419G01N33/57484G01N2333/47
Inventor 舒兴盛李田园成迎端张清
Owner SHENZHEN UNIV
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