System for evaluating sex hormone metabolic status of individuals to be detected

A sex hormone, to-be-detected technology, applied in the field of human hormone metabolism state assessment, can solve problems such as inaccurate values, interference with test results, etc., achieve low misjudgment rate, high compliance, and improve the effect of sex hormone metabolism state in the body

Active Publication Date: 2017-01-25
南京精全生物医药科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Special blood samples, such as hemolysis, jaundice, lipemia, etc., will interfere with the test results and obtain inaccurate values

Method used

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  • System for evaluating sex hormone metabolic status of individuals to be detected
  • System for evaluating sex hormone metabolic status of individuals to be detected
  • System for evaluating sex hormone metabolic status of individuals to be detected

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1 uses the system voting result of the present invention to determine the individual sex hormone metabolism state to be detected

[0042] The system includes a data collection module, a training module and a voting module; the data collection module is used to collect the levels of sex hormones and their metabolites of normal individuals and other clinical influencing factors, as well as the levels of sex hormones and their metabolites of individuals suffering from sex hormone-related diseases and other clinical influencing factors; the training module is used to utilize the R language software to divide the collected data into training sets corresponding to the above-mentioned normal individuals and individuals with sex hormone-related diseases through the bootstrap method; the voting module is used to pass random The forest method uses the above-mentioned training set to vote on the metabolic state of sex hormones of at least one sex hormone and its metaboli...

Embodiment 2

[0067] Example 2 Using the method and system of the present invention to determine the levels of sex hormones and their metabolites that have the greatest impact on breast cancer

[0068] Through the random forest method, the (MeanDecreaseGini) of each sex hormone and its metabolites in the incidence of sex hormone-related diseases is obtained, so as to find out the metabolites that have the greatest impact on sex hormone-related diseases. The average Gini index reflects the importance of variables in the random forest method index of.

[0069] The data in the table 1-3 in the embodiment 1 is utilized the random forest (RF) method to calculate the average Gini index of 29 sex hormones and metabolite indexes thereof and age and BMI, the result is as follows figure 1 , where the ordinate is the average Gini index, and the circles represent sex hormones and their metabolites. It can be seen that 4-hydroxyestrone is the most influential index on the incidence of breast cancer, fo...

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Abstract

The invention provides a system for evaluating a sex hormone metabolic status of individuals to be detected. The system comprises a data acquisition module, a training module and a voting module; the data acquisition module is used for acquiring sex hormones of normal individuals and individuals with sex hormone related diseases, metabolite levels of the sex hormones and other clinical influence factors; the training module is used for dividing acquired data into training sets, which correspond to the normal individuals and the individuals with the diseases one by one, by utilizing R language software through a bootstrap method; the voting module is used for carrying out sex hormone metabolic status voting on at least one sex hormone and the metabolite level thereof and the other clinical influence factors of the individuals to be detected by utilizing the training sets through a random forest method, and determining the sex hormone metabolic status of the individuals to be detected according to a voting result. According to the scheme provided by the invention, the sex hormone metabolic status of the individuals to be detected can be accurately determined, and the sex hormones, which have the greatest influences on the sex hormone related diseases, and the metabolite levels of the sex hormones are analyzed.

Description

technical field [0001] The invention relates to the field of evaluation of human hormone metabolism state, in particular to a method and system for evaluating the state of sex hormone metabolism of an individual to be detected. Background technique [0002] At present, it is believed that every link in the anabolic process of sex hormones is related to the occurrence of different diseases, especially the occurrence of tumors closely related to sex hormones. It is of great significance to evaluate the metabolic state of human sex hormones. The synthesis process of sex hormones begins with cholesterol, and through a complicated process, progesterone, androgen and estrogen are synthesized successively. [0003] Progesterone plays an important role in the physiological process of women's menstruation and pregnancy. Progesterone acts on the endometrium to further develop the proliferative endometrium and produce secretion, which is conducive to the implantation and growth of fe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/74
CPCG01N33/74
Inventor 缪苏宇史跃年
Owner 南京精全生物医药科技有限公司
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