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MIT biomarkers and methods using the same

A biomarker and therapy technology, applied in biochemical equipment and methods, microbial assay/test, drug combination, etc., can solve problems such as no proven efficacy of treatment and incurable disease

Active Publication Date: 2017-05-10
F HOFFMANN LA ROCHE & CO AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Once nccRCC has metastasized, the disease generally remains incurable
Although several drugs have recently been approved for metastatic RCC, few registry trials have involved patients with ccRCC, and no treatment has demonstrated efficacy in the nccRCC subtype (Bellmunt and Dutcher, 2013)

Method used

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  • MIT biomarkers and methods using the same
  • MIT biomarkers and methods using the same
  • MIT biomarkers and methods using the same

Examples

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Embodiment

[0447] The following are examples of methods and compositions of the invention. It is understood that various other embodiments may be practiced, given the general description provided above.

[0448] Materials and methods used in the examples

[0449] Samples, DNA and RNA preparation: 167 human primary nccRCC samples and their adjacent normal tissues were analyzed in this study. nccRCC samples included 67 pRCCs, 49 chRCCs, 35 ROs, 8 cancers of unclassified type, 6 tRCCs and 2 samples with sarcomatoid dedifferentiation (Tables 2 and 3).

[0450] Table 2: Sample Summary Table

[0451]

[0452]

[0453] Table 3: Sample Information

[0454]

[0455]

[0456]

[0457]

[0458]

[0459]

[0460]

[0461] The samples used in this study were obtained from patients undergoing surgery for renal mass or metastasis of RCC at Saint Paul University Hospital, Parkland Memorial Hospital and Zale Lipshy University Hospital. These hospitals represent tertiary car...

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Abstract

The invention relates to MIT biomarkers and methods using the same. Provided are therapies related to the treatment of pathological conditions, such as cancer.

Description

[0001] Cross References to Related Applications [0002] This application claims provisional U.S. Application No. 62 / 002,612, filed May 23, 2014; U.S. Application No. 62 / 059,362, filed October 3, 2014; and U.S. Application No. Priority of 62 / 109,775, hereby incorporated by reference in its entirety. [0003] sequence listing [0004] This application, containing a Sequence Listing, has been filed with EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on May 21, 2015, is named P05829-WO_SL.txt and is 85,027 bytes in size. [0005] field of invention [0006] Provided are therapies involving the treatment of pathological conditions, such as cancer. [0007] Background of the invention [0008] Kidney cancer accounts for ~60,000 new cases and ~13,000 deaths annually in the United States (Siegel et al., 2013). About 85% of kidney cancers are renal cell carcinomas (RCC), which arise from the renal epithelium. Clear cell RCC (ccRCC), acco...

Claims

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Application Information

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IPC IPC(8): C12Q1/68
CPCC12Q1/6886C12Q2600/158A61P13/12A61P35/00C12Q2600/118C12Q2600/156C12Q2600/106G01N33/57438G01N33/574
Inventor Z·莫德鲁桑S·塞沙基里B·雅瑟瓦尔N·张S·杜林克E·斯塔维斯基
Owner F HOFFMANN LA ROCHE & CO AG
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