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A preparation method of a nanometer elemental bismuth diagnostic and therapeutic agent for CT/PAT contrast imaging and photothermal therapy

A technology of nano-element and photothermal therapy, which is applied in the field of nano-materials and molecular medicine, can solve the problems of complex preparation process, high price, and insufficient biocompatibility, and achieve strong X-ray absorption ability, large X-ray attenuation coefficient, The effect of good dispersion and biocompatibility

Inactive Publication Date: 2019-07-16
ZHONGNAN HOSPITAL OF WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current metal nanocontrast agents generally have problems such as high price, complicated preparation process, and insufficient biocompatibility.

Method used

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  • A preparation method of a nanometer elemental bismuth diagnostic and therapeutic agent for CT/PAT contrast imaging and photothermal therapy
  • A preparation method of a nanometer elemental bismuth diagnostic and therapeutic agent for CT/PAT contrast imaging and photothermal therapy
  • A preparation method of a nanometer elemental bismuth diagnostic and therapeutic agent for CT/PAT contrast imaging and photothermal therapy

Examples

Experimental program
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Effect test

Embodiment 1

[0025] A method for preparing a nanometer elemental bismuth diagnostic agent, comprising the following steps:

[0026] 1) Mix n-dodecanethiol with Bi(NO 3 ) 3 ·5H 2 O was mixed at a molar ratio of 1:3, heated to 178°C with a heating mantle, kept for one minute, and then cooled down to 30°C under natural conditions, and the whole process was carried out under stirring and nitrogen gas. Filtration, the obtained solid was eluted three times with absolute ethanol (rotating speed 8000r / min, 15min / time), chloroform was eluted once (rotating speed 3000r / min, 8min / time), evaporated to dryness at 40°C to remove chloroform, and the obtained product That is, nano elemental bismuth crystals wrapped in n-dodecanethiol.

[0027] 2) Disperse the obtained n-dodecanethiol-wrapped nano elemental bismuth crystals in a mixed solvent of cyclohexane and water (the volume ratio of cyclohexane to water is 1:3), so that the crystal concentration is 60mg / ml, and ultrasonic for 30min After that, add...

Embodiment 2

[0031] A method for preparing a nanometer elemental bismuth diagnostic agent, comprising the following steps:

[0032] 1) Combine oleylamine with Bi(NO 3 ) 3 ·5H 2 O was mixed at a molar ratio of 1:7, heated to 170°C with a heating mantle, kept for 2 minutes, and cooled down to 40°C under natural conditions, and the whole process was carried out under stirring while nitrogen was passed. Filtration, eluting the resulting solid with absolute ethanol twice, chloroform twice, and evaporating to dryness to remove the chloroform, the obtained product is nanometer elemental bismuth crystals wrapped in oleylamine.

[0033] 2) Disperse the obtained nanometer elemental bismuth crystals wrapped in oleylamine in a mixed solvent of chloroform and water (volume ratio of chloroform and water: 1:1), so that the crystal concentration is 20mg / ml, and after ultrasonication for 30min, add mercaptopolyethylene Alcohol, mercapto polyethylene glycol and elemental bismuth in a molar ratio of 1:1, ...

Embodiment 3

[0035] A method for preparing a nanometer elemental bismuth diagnostic agent, comprising the following steps:

[0036] 1) Combine tert-dodecanethiol with Bi(NO 3 ) 3 ·5H 2 O was mixed at a molar ratio of 1:1, heated to 180°C using a heating mantle, kept for 1 minute, and cooled to 20°C naturally, and the whole process was carried out under stirring while nitrogen was passed. Filtration, eluting the obtained solid once with absolute ethanol and once with chloroform, and evaporating to dryness to remove the chloroform, the obtained product is nanometer elemental bismuth crystals wrapped in tert-dodecanethiol.

[0037] 2) Disperse the obtained nanometer elemental bismuth crystals wrapped in tert-dodecanethiol in a mixed solvent of toluene and water (volume ratio of toluene and water: 1:5), so that the crystal concentration is 100 mg / ml, after ultrasonication for 30 minutes, add phospholipids The molar ratio of polyethylene glycol, phospholipid polyethylene glycol and elemental...

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Abstract

The invention discloses a preparation method of a nano simple-substance bismuth diagnosis and treatment agent for CT (computed tomography) / PAT (pericardial adipose tissue) imaging. The method comprises the following steps: carrying out reaction on a hydrophobic reducing organic solvent and Bi(NO3)3 to generate a hydrophobic-molecule-coated nano simple-substance bismuth crystal, and carrying out reaction on the hydrophobic-molecule-coated nano simple-substance bismuth crystal and an amphiphilic polymer in a hydrophobic organic solvent-water mixed solution. The nano simple-substance bismuth diagnosis and treatment agent has the functions of CT imaging reinforcement and PAT imaging reinforcement, has favorable photothermal effects, can simultaneously implement the integrated diagnosis and treatment process composed of tumor preoperative diagnosis, intraoperative tracking, post-operative evaluation and the like, and thus, has favorable development potential.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials and molecular medicine, and in particular relates to a preparation method of a nanometer elemental bismuth diagnosis and treatment agent. Background technique [0002] For the treatment of tumor patients, the limitations of the traditional three major treatment methods radiotherapy, chemotherapy and surgery are becoming more and more obvious, such as lack of selectivity to the lesion, large trauma, and inability to achieve individualized treatment. Therefore, it is urgent to develop new treatment to resolve it. At present, photothermal therapy (PTT) is a minimally invasive tumor treatment technology that has developed rapidly in recent years, and is considered to be a tumor treatment method with great potential to replace surgery. Under the excitation of incident light, the photosensitizer targeting the tumor can use its photothermal conversion effect to generate heat, which can increase th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/22A61K49/04A61K41/00A61P35/00
CPCA61K41/0052A61K49/0002A61K49/04A61K49/225
Inventor 徐海波吴波陆树婷黄世文程震廖如芳喻会李玉爽
Owner ZHONGNAN HOSPITAL OF WUHAN UNIV
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