Three-layer pointed composite particles improving fracture healing

Abstract

The invention provides a three-layer pointed composite particle for improving fracture healing, which includes a granular biofilm with a width to height ratio of 2:1 to 1:1, an elastic layer from the inside to the outside of the granular biofilm, and a medicine layer, the elastic layer is a dense degradable or absorbable biofilm, the material of the drug layer is a degradable or non-degradable, absorbable or non-absorbable porous material that is biocompatible with human bone, and the drug layer also contains Sealed with drugs that can promote bone healing, the biological microstructure membrane is a long strip-shaped folded structure with a "V"-shaped cross section, an elastic layer inside and a drug layer outside, and the "V"-shaped The section width to depth ratio is 0.5‑1.5, with the width being the gap between fractured bone surfaces spliced ​​together after fracture surgery.

Description

technical field [0001] The invention relates to a three-layer pointed composite particle for improving fracture healing. Background technique [0002] At present, it is a frontier field of medical research to use a biocomposite film containing growth factors / stem cells to stick to the fracture line to enhance the speed and quality of fracture healing. There are blood vessels and bone cells distributed on the inner surface of the fracture line (anastomosis line), and whether the healing is good depends on the growth of blood vessels and bone cells in the fracture line. The reason why biofilm sticking to the surface of fracture anastomosis can increase the quality of fracture healing is that on the one hand, the drugs encapsulated in the biofilm can promote the growth of blood vessels and bone cells in the fracture anastomosis, and on the other hand, the biological The membrane isolates external muscles and other human tissues from the fracture anastomotic line, and prevents ...

AI Technical Summary

Problems solved by technology

[0004] 1. The biocomposite membrane has a relatively large volume area and a small fracture area, and 2 cannot be effectively fitted and fixed together

[0005] 2. The limitations of the current biocomposite membrane materials and manufacturing process lead to performance indicators such as the degradation rate of the biocomposite membrane and the time for the carried growth factors to release the effective drug concentration (the duration of the effective concentration is the key to the healing quality of the fracture line) Unable to meet clinical needs

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