Batch production method of pointed three-layer biological membrane

Abstract

The invention provides a batch production method of a pointed three-layer biological membrane. The method comprises steps as follows: 1) a model which has a diamond section, V-shaped vertex angles onthe long edges as well as matched vertex angles and bone fracture line section is made in advance; 2) the model is soaked in a first solution layer, a second solution layer and a third solution layersequentially, wherein the first solution layer forms an elastic layer which is a compact and degradable or non-degradable biological membrane, the second solution layer is a medicine layer, is coatedwith a drug release system with a promoting function on bone healing and is made of a degradable or non-degradable material with good biocompatibility with human bone, and the third solution layer isa guide layer and is made of a degradable or non-degradable and absorbent or non-absorbent porous bulk material with good biocompatibility with human bone; 3) when a biological microstructural membrane is air-dried and has a fixed shape, the well prepared biological microstructural membrane in required size is cut along the circumference of the section of the model, the cut annular biological membrane is stripped from the vertex angles; 4) the annular biological membrane is sheared, and the V-shaped biological membrane is obtained.

Description

technical field [0001] The invention relates to a batch production method of a pointed three-layer biofilm. Background technique [0002] At present, it is a frontier field of medical research to use a biocomposite film containing growth factors / stem cells to stick to the fracture line to enhance the speed and quality of fracture healing. There are blood vessels and bone cells distributed on the inner surface of the fracture line (anastomosis line), and whether the healing is good depends on the growth of blood vessels and bone cells in the fracture line. The reason why biofilm sticking to the surface of fracture anastomosis can increase the quality of fracture healing is that on the one hand, the drugs encapsulated in the biofilm can promote the growth of blood vessels and bone cells in the fracture anastomosis, and on the other hand, the biological The membrane isolates external muscles and other human tissues from the fracture anastomotic line, and prevents the reactio...

AI Technical Summary

Problems solved by technology

[0004] 1. The biocomposite membrane has a relatively large volume area and a small fracture area, and 2 cannot be effectively fitted and fixed together

[0005] 2. The limitations of the current biocomposite membrane materials and manufacturing process lead to performance indicators such as the degradation rate of the biocomposite membrane and the time for the carried growth factors to release the effective drug concentration (the duration of the effective concentration is the key to the healing quality of the fracture line) Unable to meet clinical needs

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