Batch making method for circular three-layer biofilm

Abstract

The invention provides a batch production method of a circular three-layer biofilm, which includes the following steps: 1) making a model in advance with an elliptical cross-section, a "U"-shaped apex angle on the long side, and a coincident apex angle with the fracture line section; 2) The model is immersed in the first solution layer, the second solution layer, and the third solution layer in turn. The first solution forms an elastic layer, which is a dense degradable or non-degradable biofilm. The second solution layer forms a drug layer, which encapsulates the bone The drug slow-release system that can promote bone healing is made of degradable or absorbable substances that are biocompatible with human bone. The third solution layer forms a guiding layer, and the material is biodegradable and biocompatible with human bone. Or non-degradable, absorbent or non-absorbing porous substances; 3) After the bio-microstructure membrane is air-dried and the shape is fixed, cut the prepared bio-microstructure membrane along the circumference of the model cross-section ellipse according to the required size, and after cutting A ring-shaped biofilm peeled from the top corner of the model.

Description

technical field [0001] The invention relates to a batch production method of a circular three-layer biofilm. Background technique [0002] At present, it is a frontier field of medical research to use a biocomposite film containing growth factors / stem cells to stick to the fracture line to enhance the speed and quality of fracture healing. There are blood vessels and bone cells distributed on the inner surface of the fracture line (anastomosis line), and whether the healing is good depends on the growth of blood vessels and bone cells in the fracture line. The reason why biofilm sticking to the surface of fracture anastomosis can increase the quality of fracture healing is that on the one hand, the drugs encapsulated in the biofilm can promote the growth of blood vessels and bone cells in the fracture anastomosis, and on the other hand, the biological The membrane isolates external muscles and other human tissues from the fracture anastomotic line, and prevents the reaction...

AI Technical Summary

Problems solved by technology

[0004] 1. The biocomposite membrane has a relatively large volume area and a small fracture area, and 2 cannot be effectively fitted and fixed together

[0005] 2. The limitations of the current biocomposite membrane materials and manufacturing process lead to performance indicators such as the degradation rate of the biocomposite membrane and the time for the carried growth factors to release the effective drug concentration (the duration of the effective concentration is the key to the healing quality of the fracture line) Unable to meet clinical needs

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