Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Molecular marker mir-4270 for predicting lung cancer brain metastases and its application in drugs and diagnostic kits

A brain metastasis and drug technology, applied in the field of molecular biology, can solve the problem of difficult early detection of brain metastasis, and achieve the effect of clear clinical efficacy and high accuracy

Active Publication Date: 2020-07-31
唐山市人民医院
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In order to solve the current technical problem that the early detection of brain metastases in patients with non-small cell lung cancer is difficult, and the risk of brain metastases in patients with non-small cell lung cancer cannot be effectively detected by molecular level detection, the present invention provides a molecular marker for predicting brain metastases of lung cancer miR- 4270 and its application in pharmaceuticals and diagnostic kits

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Molecular marker mir-4270 for predicting lung cancer brain metastases and its application in drugs and diagnostic kits
  • Molecular marker mir-4270 for predicting lung cancer brain metastases and its application in drugs and diagnostic kits
  • Molecular marker mir-4270 for predicting lung cancer brain metastases and its application in drugs and diagnostic kits

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0042] The present invention will be further described below in conjunction with the accompanying drawings and embodiments, but the embodiments do not constitute any limitation to the present invention.

[0043] The experimental methods used in the following examples are conventional methods unless otherwise specified.

[0044] The materials and reagents used in the following examples can be obtained from commercial sources unless otherwise specified.

[0045] The experimental methods for the specific conditions not indicated in the examples are generally conventional methods in the art.

[0046] The detection methods involved in this example include microRNA probe design, extraction, qRT-PCR verification, cell proliferation, colony formation, invasion and metastasis experiments, nude mice subcutaneous tumor transplantation and metastatic tumor treatment experiments. In future clinical applications, only microRNA extraction and qRT-PCR will be used. These two methods are rou...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
thicknessaaaaaaaaaa
Login to View More

Abstract

The invention belongs to the technical field of molecular biology, and discloses a molecular marker miR-4270 for predicating brain metastasis from lung cancer and application thereof to medicine and diagnostic kits. The invention discloses application of the miR-4270 to the preparation of medicine with effect of inhibiting tumor, application of the miR-4270 to the preparation of medicine with effect of inhibiting of brain metastasis from lung cancer and application of the molecular marker miR-4270 to the preparation of the diagnostic kits for predicating non-small-cell lung cancer producing brain metastases. The miR-4270 adopts a molecular biological technology, can effectively perform detection on molecular level to judge brain metastases of non-small-cell lung cancer patients and a markfor targeted therapy, and further provides convenience for individualized treatment of the diseases. The miR-4270 has important guiding significance for the carrying out of subsequent clinical research.

Description

technical field [0001] The invention belongs to the technical field of molecular biology, and in particular relates to a group of molecular markers miR-4270 for predicting brain metastases of lung cancer and its application in medicine and diagnostic kits. Background technique [0002] Worldwide, lung cancer is the leading cause of cancer death. Non-small cell lung cancer accounts for about 80% of all lung cancers, and about 25% of non-small cell lung cancer patients will develop brain metastases. Locally advanced non-small cell lung cancer accounts for about 40% of non-small cell lung cancer, and brain metastasis is one of the most common failures after comprehensive treatment of locally advanced non-small cell lung cancer. The risk of brain metastases in patients with early-stage NSCLC is 10%. However, locally advanced NSCLC has a high risk of brain metastases, about 30-50%. Brain metastases seriously endanger the survival and quality of life of patients. Advances in s...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7105A61P35/00C12N15/113C12Q1/6886
CPCA61K31/7105C12N15/113C12N2310/141C12Q1/6886C12Q2600/158C12Q2600/178
Inventor 孙国贵胡万宁
Owner 唐山市人民医院
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com