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Lung cancer diagnostic marker microRNA-4317 and its application in drugs and diagnostic kits

A tumor drug, non-small cell lung cancer technology, applied in the field of molecular biology to achieve the effect of improving accuracy

Active Publication Date: 2020-11-20
唐山市人民医院
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Current clinicopathological staging has limitations in predicting brain metastases in patients

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  • Lung cancer diagnostic marker microRNA-4317 and its application in drugs and diagnostic kits
  • Lung cancer diagnostic marker microRNA-4317 and its application in drugs and diagnostic kits
  • Lung cancer diagnostic marker microRNA-4317 and its application in drugs and diagnostic kits

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Embodiment Construction

[0038] The present invention will be further described below in conjunction with the accompanying drawings and embodiments, but the embodiments do not constitute any limitation to the present invention.

[0039] The experimental methods used in the following examples are conventional methods unless otherwise specified.

[0040] The materials and reagents used in the following examples can be obtained from commercial sources unless otherwise specified.

[0041] The experimental methods for the specific conditions not indicated in the examples are generally conventional methods in the art.

[0042] In this implementation, the methods for finding markers for metastasis, prognosis and targeted therapy of non-small cell lung cancer are as follows:

[0043] 1. Patients and Specimens:

[0044] From July 2004 to June 2009, 162 patients with paraffin wax specimens of non-small cell lung cancer confirmed by pathology after complete resection and who had not received radiotherapy, chemot...

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Abstract

The invention belongs to the technical field of molecular biology and discloses a group of molecular markers microRNA-4317 for metastasis, prognosis and targeted therapy of non-small-cell lung carcinoma, an application of the molecular markers to preparation of a diagnostic reagent or kit for metastasis, prognosis and targeted therapy of non-small-cell lung carcinoma, as well as an application ofmicroRNA-4317 to preparation of a tumor inhibition drug and an application of the gene expression condition of microRNA-4317 to preparation of a drug for tumor inhibition prognosis or targeted therapy. By use of the molecular biological technique, the markers for metastasis, prognosis and targeted therapy of patients with non-small-cell lung carcinoma can be judged by effective molecular level detection, and convenience is provided for individualized treatment of diseases. Meanwhile, the markers have great guiding significance in development of follow-up clinical research.

Description

technical field [0001] The invention belongs to the technical field of molecular biology, and specifically relates to a group of marker gene microRNA-4317 as a non-small cell lung cancer diagnostic marker and its application in medicine and diagnostic kits. Background technique [0002] Lung cancer has always been one of the most dangerous malignant tumors, and its high morbidity and mortality are the main causes of cancer death in China and even in the world. According to the pathological type, lung cancer is mainly divided into two categories: one is small cell lung cancer, accounting for about 15% of lung cancer; the other is non-small cell lung cancer, accounting for about 85%. Although there has been some progress in lung cancer research, including early diagnosis of lung cancer patients, preoperative adjuvant chemotherapy, radiotherapy and even targeted therapy, the onset of lung cancer is hidden. Due to the timing of treatment and the lack of sensitive, specific, and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6886A61K31/7105A61P35/00
CPCA61K31/7105C12Q1/6886C12Q2600/118C12Q2600/158C12Q2600/178
Inventor 孙国贵胡万宁
Owner 唐山市人民医院
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