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Marker microRNA-10b-3p for detecting esophageal squamous carcinoma and application in kit

A microrna-10b-3p, esophageal squamous cell carcinoma technology, applied in the field of molecular biology, to achieve high precision results

Active Publication Date: 2018-10-02
唐山市人民医院
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0007] In order to solve the current technical problem of not being able to effectively carry out molecular level detection to judge the risk of metastasis of esophageal cancer, the present invention provides a molecular marker for predicting metastasis of esophageal squamous cell carcinoma microRNA-10b-3p and its application in the kit

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  • Marker microRNA-10b-3p for detecting esophageal squamous carcinoma and application in kit
  • Marker microRNA-10b-3p for detecting esophageal squamous carcinoma and application in kit
  • Marker microRNA-10b-3p for detecting esophageal squamous carcinoma and application in kit

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Embodiment Construction

[0033] The present invention will be further described below in conjunction with the accompanying drawings and embodiments, but the embodiments do not constitute any limitation to the present invention.

[0034] The experimental methods used in the following examples are conventional methods unless otherwise specified.

[0035] The materials and reagents used in the following examples can be obtained from commercial sources unless otherwise specified.

[0036] The experimental methods for the specific conditions not indicated in the examples are generally conventional methods in the art.

[0037] The detection method involved in the embodiment of the present invention includes microRNA probe design, extraction, and qRT-PCR verification experiment. In future clinical applications, only microRNA extraction and qRT-PCR will be used. These two methods are routine operations for those skilled in the art. Therefore, the model is easy to be generalized in clinic.

[0038] In this...

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Abstract

The invention belongs to the technical field of molecular biologics and particularly discloses a marker microRNA-10b-3p for detecting esophageal squamous carcinoma and the application in a kit. The invention discloses a molecular marker microRNA-10b-3p and the application of the molecular marker in preparing a kit for predicting esophageal squamous carcinoma metastasis and early-stage screening and diagnosis. By adopting a molecular biological technique, a marker for detecting esophageal squamous carcinoma metastasis and early-stage screening through effective molecular level detection is prepared, esophageal squamous carcinoma can be monitored by using the kit disclosed by the invention, the cancer can be discovered earlier than clinical signs and symptoms, references can be provided fordoctors to carry out early-stage screening, and furthermore convenience can be brought to individual treatment on diseases.

Description

technical field [0001] The invention belongs to the technical field of molecular biology, and in particular relates to a group of microRNA-10b-3p markers for predicting esophageal squamous cell carcinoma and the application in the kit. Background technique [0002] Esophageal cancer is one of the most serious malignant tumors that endanger the health of Chinese people. According to the latest statistics of the World Health Organization in 2013, the incidence of esophageal cancer ranks fifth among malignant tumors in my country, and its mortality rate ranks fourth. The number of people who die from esophageal cancer in China is 197,472 every year, more than half of the total deaths from esophageal cancer in the world. At the same time, due to differences in ethnicity between the East and the West and the etiology of esophageal cancer, the characteristics of esophageal cancer in my country are significantly different from those in low-incidence areas such as Europe and the Uni...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/118C12Q2600/156C12Q2600/178
Inventor 孙国贵胡万宁
Owner 唐山市人民医院
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