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The application of the marker mir-652-5p on the metastasis, prognosis and treatment of esophageal squamous cell carcinoma in drugs and kits

A technology for esophageal squamous cell carcinoma and esophageal cancer, which is applied in the field of molecular biology to achieve high-precision effects

Active Publication Date: 2022-03-11
唐山市人民医院
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Problems solved by technology

[0008] In order to solve the current technical problem of not being able to effectively carry out molecular level detection to judge the risk of metastasis of esophageal cancer, the present invention provides a molecular marker for predicting metastasis of esophageal squamous cell carcinoma microRNA-652-5p and its application in medicines and kits

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  • The application of the marker mir-652-5p on the metastasis, prognosis and treatment of esophageal squamous cell carcinoma in drugs and kits
  • The application of the marker mir-652-5p on the metastasis, prognosis and treatment of esophageal squamous cell carcinoma in drugs and kits
  • The application of the marker mir-652-5p on the metastasis, prognosis and treatment of esophageal squamous cell carcinoma in drugs and kits

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[0039] The present invention will be further described below in conjunction with the accompanying drawings and embodiments, but the embodiments do not constitute any limitation to the present invention.

[0040] The experimental methods used in the following examples are conventional methods unless otherwise specified.

[0041] The materials and reagents used in the following examples can be obtained from commercial sources unless otherwise specified.

[0042] The experimental methods for the specific conditions not indicated in the examples are generally conventional methods in the art.

[0043] The detection method involved in this embodiment includes microRNA probe design, extraction, in situ hybridization, qRT-PCR verification, cell proliferation, clonal colony formation, and invasion and metastasis experiments. In future clinical applications, only microRNA extraction and qRT-PCR will be used. These two methods are routine operations for those skilled in the art. Therefor...

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Abstract

The invention belongs to the technical field of molecular biology, and specifically relates to the application of a marker miR-652-5p in drugs and kits for the metastasis, prognosis and treatment of esophageal squamous cell carcinoma. The invention discloses the application of microRNA-652-5p in the preparation of drugs capable of inhibiting tumors, the application of microRNA-652-5p in the preparation of drugs capable of inhibiting the metastasis of esophageal squamous cell carcinoma, and the application of molecular marker microRNA-652-5p in the preparation of drugs for predicting esophageal squamous cell carcinoma. Application in cancer metastasis diagnostic kit. The invention utilizes molecular biology technology to effectively detect the markers of metastasis and targeted therapy in patients with esophageal squamous cell carcinoma through molecular level detection, thereby providing convenience for individualized treatment of these diseases. At the same time, it has important guiding significance for the development of follow-up clinical research.

Description

technical field [0001] The invention belongs to the technical field of molecular biology, and specifically relates to the application of a marker miR-652-5p in drugs and kits for metastasis, prognosis and treatment of esophageal squamous cell carcinoma. Background technique [0002] Esophageal cancer is one of the most serious malignant tumors that endanger the health of Chinese people. According to the latest statistics of the World Health Organization in 2013, the incidence of esophageal cancer ranks fifth among malignant tumors in my country, and its mortality rate ranks fourth. The number of people who die from esophageal cancer in China is 197,472 every year, more than half of the total deaths from esophageal cancer in the world. At the same time, due to differences in ethnicity between the East and the West and the etiology of esophageal cancer, the characteristics of esophageal cancer in my country are significantly different from those in low-incidence areas such as ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N15/113
CPCA61P35/00A61P35/04A61K31/7105C12Q1/6886C12Q2600/118C12Q2600/178
Inventor 孙国贵胡万宁
Owner 唐山市人民医院
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