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Application of hexahydroadiphenine and pharmaceutically acceptable salts thereof in preparation of medicines for treating Alzheimer disease

A technology of Alzheimer's disease and hexahydrofenine, applied in the new application field of medicine

Inactive Publication Date: 2018-06-22
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no report on its protective effect on neurons and/or increasing Aβ clearance a

Method used

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  • Application of hexahydroadiphenine and pharmaceutically acceptable salts thereof in preparation of medicines for treating Alzheimer disease
  • Application of hexahydroadiphenine and pharmaceutically acceptable salts thereof in preparation of medicines for treating Alzheimer disease
  • Application of hexahydroadiphenine and pharmaceutically acceptable salts thereof in preparation of medicines for treating Alzheimer disease

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Abstract

The invention discloses application of hexahydroadiphenine and pharmaceutically acceptable salts thereof in preparation of medicines for treating Alzheimer disease, and the medicines for treating andprotecting neurons and/or promoting A beta removal and/or inhibiting Tau protein phosphorylation-related neurodegenerative disease (such as Parkinson's disease). After a large number of experimental screening is performed, the experimental results prove that the hexahydroadiphenine and the pharmaceutically acceptable salts thereof can obviously protect neural tool cells SH-SY5Y and prevent the primary neurons from STZ damage, can promote the removal of exogenous A beta by using BV2 cells, can obviously inhibit the phosphorylation level of Tau protein in the primary neuronal cells, thus being developed as new clinical medicines for treating the Alzheimer disease.

Description

technical field [0001] The present invention relates to the technical field of new application of medicines, in particular to the application of hexahydrofenine and its pharmaceutical composition in the preparation of medicines for treating Alzheimer's disease, more specifically, the present invention relates to hexahydrofenine and its pharmaceutical The above acceptable salts or pharmaceutical compositions thereof have the effect of protecting neurons and / or increasing Aβ clearance and / or inhibiting Tau protein phosphorylation, and are used for the preparation of [0002] Applications in drugs for the treatment of neurodegenerative diseases such as Alzheimer's disease. Background technique [0003] Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by extraneural amyloid deposition caused by Aβ aggregation, neurofibrillary tangles caused by hyperphosphorylation of tau protein, and neuronal cell apoptosis etc. as its main symbol. AD is highly...

Claims

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Application Information

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IPC IPC(8): A61K31/216A61P25/28A61P25/16
CPCA61K31/216
Inventor 沈旭王佳颖卢健
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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