Whole blood CRP detection apparatus

A detection device and detection unit technology, which is applied in the direction of measuring devices, instruments, and material analysis through optical means, can solve the problems of reducing the accuracy of measurement results of CRP samples, and achieve the effect of avoiding inaccurate measurement results

Pending Publication Date: 2018-07-13
SHENZHEN DYMIND BIOTECH
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Problems solved by technology

[0006] The object of the present invention is to provide a whole blood CRP detection device, aiming to solve the problem of not reducing the accuracy of the measurement results of low-value CRP samples, even if the CRP concentration of the sample exceeds a certain limit, accurate CRP electrical signal values ​​can still be collected , and calculate the exact CRP result of the problem

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specific Embodiment approach

[0041] According to the obtained first CRP response signal data and second CRP response signal data, the present invention further obtains the voltage value of the CRP response curve through calculation according to the formula, and then calculates the CRP value through the initial value of the CRP response curve and hematocrit. The specific implementation is as follows:

[0042] see Figure 4 , I 1 (t) is the graph, I of the first CRP response signal data 2 (t) is a graph of the second CRP response signal data, and I(t) is a graph of the CRP response curve. The concrete method that the present invention calculates CRP response curve is as follows:

[0043]

[0044] In the formula, I(t) is the voltage value corresponding to the CRP response curve at time t; 1 (t) is the voltage value corresponding to the first CRP response signal data at t moment; I 2 (t) is the voltage value corresponding to the second CRP response signal data at t moment; TH is a preset threshold val...

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Abstract

The invention discloses a whole blood CRP detection apparatus, which comprises a sampling unit, a reagent unit, a reagent distribution unit, a red blood cell detection unit, a white blood cell detection unit, a CRP detection unit, a signal processing and acquisition unit, a storage and calculation unit and an output unit, wherein the signal processing and acquisition unit comprises a red blood cell signal processing and acquisition module, a white blood cell signal processing and acquisition module and a CRP signal processing and acquisition module, and the storage and calculation unit is usedfor performing calculation on acquired red blood cell pulse waveform data and acquired white blood cell pulse waveform data to obtain packed cell volume and performing calculation on first CRP reaction signal data and second CRP reaction signal data to obtain a CRP reaction curve, and finally calculating according to the CRP reaction curve and the packed cell volume to obtain a CRP value. With the whole blood CRP detection apparatus of the present invention, in the case of the accurate measurement of the low-value CRP sample, the upper limit of the measurement range of the CRP can be improved, and the inaccurate measurement result of the high-value CRP sample can be avoided.

Description

technical field [0001] The invention relates to a blood detection device, in particular to a whole blood CRP detection device. Background technique [0002] CRP (C-reactive protein) is a part of the body's non-specific immune mechanism. It can activate the classic pathway of complement, enhance the phagocytosis of white blood cells, regulate the function of lymphocytes or monocyte / macrophage system, and promote the production of macrophage tissue factor. CRP can also be detected in atherosclerotic plaques. CRP increases rapidly several hours after the inflammation begins, and reaches its peak within 48 hours (the level of CRP in serum can increase from less than 5 mg / L to 500 mg / L). to normal levels. Therefore, the test results of CRP have extremely important clinical value in the hospital. [0003] At present, many hospitals need to combine the two parameters of WBC (white blood cells) and CRP as a reference for clinical diagnosis. Correspondingly, there are more and mor...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/75G01N21/82
CPCG01N21/75G01N21/82G01N2021/7769G01N2021/7783
Inventor 唐争辉李国军刘治志
Owner SHENZHEN DYMIND BIOTECH
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