Extended duration local anesthetic formulation

Abstract

An extended duration anesthetic includes a short duration local anesthetic in a dilute solution and a long duration local anesthetic. The long duration local anesthetic is maintained in a powdered form until the time of administration. Premeasured quantities of the dilute solution and powdered long duration local anesthetic in a kit allow for quick preparation of a solution with desired concentrations of both short duration local anesthetic and long duration local anesthetic at the time of administration.

Description

technical field [0001] Embodiments of the application disclosed herein relate generally to local anesthetics, and more particularly to long-acting local anesthetics for producing prolonged analgesic effects during surgical procedures. Background technique [0002] Local anesthesia refers to any technique that induces anesthesia in a specific part of the body, usually with the aim of inducing local analgesia or localized analgesia. Regional anesthesia aims to numb a large part of the body, such as an area of ​​the arm, leg, or torso, by blocking the function of a specific nerve or nerves. Typically, various local anesthetics are injected into the surgical site or into sites adjacent to specific nerves to provide pain relief to specific areas. Current medications typically provide pain relief between 2-18 hours. Proprietary formulations of liposomal bupivacaine sold under the trade mark Exparel claim to have a duration of up to 72 hours, but such durations are generally not ...

AI Technical Summary

Problems solved by technology

Bupivacaine and etidocaine have been reported to provide major nerve block within 3 to 12 hours; unfortunately, each of these local anesthetics is also highly cardiotoxic and may be due to vascular absorption resulting in death

Some existing products use high concentrations (approximately 2%) of bupivacaine, which also causes death

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