The invention discloses a medicine for local anaesthesia and a preparation method of the medicine. The medicine comprises the following raw material medicines: Chinese angelica, cinnamon, pepper, fresh ginger, Schizonepeta, divaricate saposhnikovia root, clove, dried tangerine or orange peel, cyperus rotundus, sensitive plant, rhizoma nardostachyos, persimmon calyx, mint, radix bupleuri, henbane leaf, radix gentianae, coptis chinensis, semen strychni, patrinia, purslane, humifuse euphorbia herb, oldenlandia diffusa, root of rehmannia, sweet wormwood, cortex lycii radicis, pseudo-ginseng, rubia cordifolia, Loropetalum chinense, trogopterus dung and corydalis tuber. The medicine has the beneficial effects that the medicine has the advantages of wide clinical application safety range, zero toxic or side effect and good pain and blood stopping effects by utilizing the theory of traditional Chinese medicine, injection is not needed during use, only the medicine is needed to be dripped or smeared to an affected part needed to be operated for several times, and when the local tissue is found not to have a sense of pain, the operation can be carried out. The feared state of mind of a patient can be effectively eliminated, the feeling of the patient can be rapidly restored after the operation, and postoperative adverse reactions are reduced.