58 results about "Topical local anesthetic" patented technology

Sustained release local anesthetic formulations are administered intra articularly and/or into body spaces/cavities. The formulation is preferably a plurality of injectable microparticles including a local anesthetic and an effective amount of a biocompatible, biodegradable, sustained release material prolonging the release of the local anesthetic and optionally and a pharmaceutically acceptable, i.e., non-toxic, augmenting agent effective to prolong the duration of the local anesthesia for a time period longer than that obtainable without the augmenting agent.

The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot comprising a polymer and a therapeutically effective amount of a local anesthetic or pharmaceutically acceptable salt thereof, wherein the drug depot is implantable at a site beneath the skin to reduce, prevent or treat post-operative pain, and the drug depot is capable of releasing (i) a bolus dose of the local anesthetic or pharmaceutically acceptable salt thereof at a site beneath the skin and (ii) a sustained release dose of an effective amount of the local anesthetic or pharmaceutically acceptable salt thereof over a period of at least 4 days.

The present disclosure is drawn to methods for treating myofascial pain, muscle pain, back pain, or combinations of these pains. Specifically, a method for treating myofascial pain, muscle pain, back pain, or combinations thereof includes the application of an analgesic system to a skin surface of a subject experiencing the pain and maintaining the analgesic system on the skin surface for a period of time of at least 30 minutes. The analgesic system applied to the skin surface can include a heating component and a local anesthetic formulation which includes at least one local anesthetic. The heating component can be capable of heating the skin surface to a temperature of 36° C. to 42° C.

A method and system to treat headaches in a patient by performing surgery via at least one nostril. Data from a computer tomography scan of at least one nasal cavity and one sinus cavity of the patient and a completed headache questionnaire are matched to at least one nasal/sinus surgery plan to operate on at least one of; a nasal septum, at least one sinus cavity and at least one turbinate of the patient. The surgery plan is executed by installing a topical local anesthetic and decongestant onto the at least one turbinate forming an anesthetized decongested nasal cavity; infusing an anesthetic into the anesthetized decongested nasal cavity of the patient; dilating the at least one sinus ostium; incising at least one of: a first mucosal flap or a second mucosal Hap of the nasal septum of the anesthetized decongested nasal cavity to expose deviated septal cartilage and bone; removing deviated cartilage and/or bone of the nasal septum; fracturing the at least one turbinate laterally away from the nasal septum; inspecting between the first mucosal flap and the second mucosal flap for a residual broken hone, a residual segment of cartilage or combinations thereof, surgically closing the first mucosal flap and the second mucosal flap of the nasal septum; and suctioning unwanted matter from the anesthetized decongested nasal cavity. An interactive system guides the surgery and provides a record thereof.

Disclosed is a nasal spray containing the combination of a vasoconstrictor and a topical local anesthetic.

An object of the present invention is to provide a local anesthetic-containing composition characterized by (1) exerting immediate and long-lasting medicinal effect without sustained release after administration, and/or (2) having storage stability.

The present invention provides an acidic emulsion composition comprising a local anesthetic and a glyceride in which a fatty acid(s) having 6 to 12 carbon atoms is/are bound to glycerin via an ester bond(s).

The invention provides a pain-relieving and anti-inflammatory compound sustained-release preparation, which comprises a local anesthetic, a non-steroidal anti-inflammatory drug and a sustained-release preparation consisting of poloxamer 407 and poloxamer 188. The pain-relieving and anti-inflammatory compound sustained-release preparation disclosed by the invention is a non-opioid analgesic, is a dual-effect combined product composed of the local anesthetic and the low-dose non-steroidal anti-inflammatory drug, is specially used for treating postoperative pain and inflammation at an operative site through single administration, and has obvious advantages in efficacy, wherein the non-steroidal anti-inflammatory drug not only has an anti-inflammatory effect, but also can inhibit the formation of an acid environment and normalize the pH value, so that the permeation effect of the local anesthetic is recovered and enhanced, and the drug effect is as long as 4-5 days.

An extended duration anesthetic includes a short duration local anesthetic in a dilute solution and a long duration local anesthetic. The long duration local anesthetic is maintained in a powdered form until the time of administration. Premeasured quantities of the dilute solution and powdered long duration local anesthetic in a kit allow for quick preparation of a solution with desired concentrations of both short duration local anesthetic and long duration local anesthetic at the time of administration.

An adductor canal block introducer for introducing a catheter and also administering an initial dose of local anesthetic. The adductor canal block introducer generally includes a cannula having an elongated body with a distal end, a proximal end, and a slot extending along the elongated body, the slot having two sides and a lower surface. It also includes a cannulated trocar positioned in the slot of the cannula, the cannulated trocar having a distal end and a proximal end, wherein the trocar includes a discharge proximate to the distal end, wherein an inlet and the discharge are in fluid communication with each other. The introducer also includes a catheter positioned in the slot, held in place by the cannulated trocar. The catheter may also be positioned by a grasper introducer that holds the catheter and also includes a discharge at its distal end through which an anesthetic can be administered.

A multimodal anti-emetic anesthetic/analgesic formulation for pain control not limited to postoperative pain control is described herein. The opioid-free/sparing anesthetic/analgesic formulation comprises a local anesthetic, an N-methyl-D-aspartate (NMDA) receptor antagonist, and a cyclooxygenase (COX) inhibitor such as Bupivacaine Hydrochloride, Ketamine Hydrochloride, and Ketorolac Tromethamine, which is effective to significantly reduce postoperative nausea and vomiting and enhance postoperative pain relief as compared to existing prior art anesthetics/analgesics. The formulation is administered to a mammal in need of anesthesia/analgesia and can be used as a preemptive and preventative multimodal analgesic. The formulation may have a buffer to enhance its shelf life and improve pharmacokinetics. The formulation may further comprise an alpha agonist, a steroid, a Transient Receptor Potential Channel agonist or antagonist, a beta-lactam antibiotic, a protein kinase inhibitor, a competitive or non-competitive glycine or glutamate antagonist, a glutamate or glycine inhibitor, a cyclooxygenase 3 inhibitor, or combinations thereof.

The disclosure relates to the area of medicine and surgery, in particular it pertains to a drainage catheter (100) that comprises a high capacity drain comprising a radiological guide (110a) with a suction mesh (110b), a safety control opening/closing system (160), an internal pneumatic clamping system (140) and/or an external adhesive skin protection system (150). A reservoir for the administration of local anesthetics and antibiotics may be additionally provided. The disclosed catheter system optimizes flow surface, facilitates procedures for handling and removal of drainage, reduces the risk of occlusions, pain, injuries and infections of the surrounding skin and maintains sufficient structural strength to prevent collapses, among others.

The invention relates to an analgesic and hemostatic drug composition for external use. The formation is as follows by weight percentage: 2%-20% of cuttlebone extract, 2%-10% of colorant, 2%-10% of bacteriostatic agent, 2%-10% of local anesthetic, 20%-30% of matrix, 30%-40% of lubricant, and 15%-25% of moisturizer. The invention discloses a preparation method and use of the above composition. Thecomposition of the present invention is not only safe and reliable, without toxic and side effects, but also can protect the anorectal mucosa, promote the formation of new blood vessels in granulationtissues, eliminate peroxides, and play the roles of hemostasis and wound-healing promotion, the effect is quick, the cure rate is high, and the effect of treating hemorrhoid is good.