80results about How to "Effective pain relief" patented technology

A solid oral controlled-release oral dosage form of hydrocodone is disclosed. The dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and a sufficient amount of a controlled release material to render the dosage form suitable for twice-a-day administration to a human patient, the dosage form providing a C12 / Cmax ratio of 0.55 to 0.85, said dosage form providing a therapeutic effect for at least about 12 hours.

A solid oral controlled-release oral dosage form of hydrocodone is disclosed. The dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and a sufficient amount of a controlled release material to render the dosage form suitable for twice-a-day administration to a human patient, the dosage form providing a C12 / Cmax ratio of 0.55 to 0.85, said dosage form providing a therapeutic effect for at least about 12 hours.

A solid oral controlled-release oral dosage form of hydrocodone is disclosed. The dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and a sufficient amount of a controlled release material to render the dosage form suitable for twice-a-day administration to a human patient, the dosage form providing a C12 / Cmax ratio of 0.55 to 0.85, said dosage form providing a therapeutic effect for at least about 12 hours.

Compositions comprised of a delivery vehicle or delivery system and an active agent dispersed within the delivery vehicle or system, wherein the delivery vehicle or system contains a polyorthoester polymer and a polar aprotic solvent. Also disclosed are low viscosity delivery systems for administration of active agents. The low viscosity delivery systems have a polyorthoester polymer, a polar aprotic solvent and a solvent containing a triglyceride viscosity reducing agent. Compositions described include an amide- or anilide-type local anesthetic of the “caine” classification, and a non-steroidal anti-inflammatory drug (NSAID), along with related methods, e.g., for treatment of post-operative pain or for prophylactic treatment of pain. The compositions are suitable for delivery via, e.g., direct application and instillation, intradermal injection, subcutaneous injection, and nerve block (perineural).

A vibratory neural stimulation (VNS) system is provided to help relieve pain by applying preprogrammed or user defined patterns to the region having pain. The VNS system comprises of plurality of miniature vibration disks installed in a flexible material forming a vibration mesh. A programmable control unit (PCU) controls the vibration frequency and amplitude, and the period of activation of each vibrator. A user can search for the more effective vibration pattern to relieve his or her pain.

Intra-vaginal devices and methods are disclosed for a broad range of applications in the women's health field. The devices and methods provide for placement in the cervical region, and for transferring heat to a cervical region, a barrier contraception method, collection of menstrual fluid, and release of drugs and / or hormones intra-vaginally. The device also can address multiple women's health issues.

The method and device of the present invention for pain relief using ultrasound waves in combination with cryogenic energy includes a generator and a transducer to produce ultrasonic waves and a cryogenic source to produce cryogenic energy. Ultrasound waves are delivered to the target in combination with cryogenic energy. Ultrasound waves and cryogenic energy can be delivered to the target from the radial side of the ultrasound horn and / or tip or can be delivered from the distal end of the ultrasound tip. Cryogenic energy can also be delivered directly to the target through a central orifice. Ultrasound energy can also be delivered through a cryogenic spray at the distal end. The use of ultrasound waves in combination with cryogenic energy can provide an analgesic effect.

Compositions comprised of a delivery vehicle or delivery system and an active agent dispersed within the delivery vehicle or system, wherein the delivery vehicle or system contains a polyorthoester polymer and a polar aprotic solvent. Also disclosed are low viscosity delivery systems for administration of active agents. The low viscosity delivery systems have a polyorthoester polymer, a polar aprotic solvent and a solvent containing a triglyceride viscosity reducing agent. Compositions described include an amide- or anilide-type local anesthetic of the “caine” classification, and a non-steroidal anti-inflammatory drug (NSAID), along with related methods, e.g., for treatment of post-operative pain or for prophylactic treatment of pain. The compositions are suitable for delivery via, e.g., direct application and instillation, intradermal injection, subcutaneous injection, and nerve block (perineural).

Compositions comprised of a delivery vehicle or delivery system and an active agent dispersed within the delivery vehicle or system, wherein the delivery vehicle or system contains a polyorthoester polymer and a polar aprotic solvent. Also disclosed are low viscosity delivery systems for administration of active agents. The low viscosity delivery systems have a polyorthoester polymer, a polar aprotic solvent and a solvent containing a triglyceride viscosity reducing agent. Compositions described include an amide- or anilide-type local anesthetic of the “caine” classification, and a non-steroidal anti-inflammatory drug (NSAID), along with related methods, e.g., for treatment of post-operative pain or for prophylactic treatment of pain. The compositions are suitable for delivery via, e.g., direct application and instillation, intradermal injection, subcutaneous injection, and nerve block (perineural).

A specific dosage regimen of buprenorphine achieves pain relief from painful episodes due to sickle cell disease. The dosage regimen comprises administering to a patient in need of pain relief from sickle cell disease at least one BTDS transdermal patch. Alternatively, the dosing regimen comprises administering to the patient (1) a first buprenorphine-containing transdermal dosage form for a first dosing period; (2) administering to the patient a second buprenorphine-containing transdermal dosage form for a second dosing period, where the second dosage form comprises the same dosage of buprenorphine as, or a greater dosage of buprenorphine than, the first dosage form; and (3) administering to the patient a third buprenorphine-containing transdermal dosage form for a third dosing period, where the third dosage form comprises a greater dosage of buprenorphine than the second dosage form.

The invention aims at providing a biological air freshening disinfectant, which is characterized by being prepared from the following raw materials in parts by mass: 1 to 3 parts of camphor, 2 to 4 parts of menthol, 2 to 4 parts of eucalyptus oil, 1 to 3 parts of borneol, 0.5 to 1.5 parts of clove oil, 0.5 to 1.5 parts of perilla leaf oil, 0.5 to 1.5 parts of patchouli oil, 0.5 to 1.5 parts of rosemasry oil and 70 to 90 parts of solvents. The biological air freshening disinfectant provided by the invention is applicable to indoor places such as living hours, bedrooms, washrooms, living rooms, kitchens, automobiles and offices, has the effects of killing bacteria and viruses, preventing influenza, expelling parasite, preventing mosquitoes, freshening the air and refreshing the brain, does not have toxic and side effects on human bodies, and belongs to the biological air freshening disinfectant capable of being used by old people, children and weak people.

Compositions comprised of a delivery vehicle or delivery system and an active agent dispersed within the delivery vehicle or system, wherein the delivery vehicle or system contains a polyorthoester polymer and a polar aprotic solvent. Also disclosed are low viscosity delivery systems for administration of active agents. The low viscosity delivery systems have a polyorthoester polymer, a polar aprotic solvent and a solvent containing a triglyceride viscosity reducing agent. Compositions described include an amide- or anilide-type local anesthetic of the “caine” classification, and a non-steroidal anti-inflammatory drug (NSAID), along with related methods, e.g., for treatment of post-operative pain or for prophylactic treatment of pain. The compositions are suitable for delivery via, e.g., direct application and instillation, intradermal injection, subcutaneous injection, and nerve block (perineural).

Compositions comprised of a delivery vehicle or delivery system and an active agent dispersed within the delivery vehicle or system, wherein the delivery vehicle or system contains a polyorthoester polymer and a polar aprotic solvent. Also disclosed are low viscosity delivery systems for administration of active agents. The low viscosity delivery systems have a polyorthoester polymer, a polar aprotic solvent and a solvent containing a triglyceride viscosity reducing agent. Compositions described include an amide- or anilide-type local anesthetic of the “caine” classification, and a non-steroidal anti-inflammatory drug (NSAID), along with related methods, e.g., for treatment of post-operative pain or for prophylactic treatment of pain. The compositions are suitable for delivery via, e.g., direct application and instillation, intradermal injection, subcutaneous injection, and nerve block (perineural).

The invention relates to cyclic peptide agonists that bind to the mu (morphine) opioid receptor and their use in the treatment of acute and / or chronic pain. Embodiments of the invention are directed to cyclic pentapeptide and hexapeptide analogs of endomorphin that have (i) a carboxy-terminal extension with an amidated amino acid and (ii) a D-amino acid substitution in position 2. These peptide analogs exhibit decreased tolerance relative to morphine, increased solubility compared to similar tetrapeptide analogs, while maintaining favorable or improved therapeutic ratios of analgesia to side effects.

A Chinese medicine for treating mastoplasia and breast edema is prepared from 10 Chinese-medicinal materials including turtle shell, curcuma root, bupleurum root, prunella spike, etc.

The invention discloses a pulsed magnet field analgesic apparatus. According to the pain sensory nerve conduction and control mechanism and the effective clinical basis of transcutaneous electrical stimulation and transcranial magnetic stimulation analgesia, a side-effect-free, efficient and safe pulsed magnetic stimulation analgesic apparatus and an analgesic operation method are designed. A maincircuit emits pulse current to a stimulation coil by an energy-storage capacitor with the adjustable voltage through a full-bridge switch circuit, a pulsed magnet field is generated for analgesia, the alternating current-direct current and direct current-direct current voltage conversion process is adopted, equipment electromagnetic interference is removed through an alternating-current power supply filtration module, alternating current is rectified through a rectifying module to form direct current, and the circuit is adjusted through power factors so that the current waveform of equipmentcan be coincident with the voltage waveform of the equipment; through a direct current-direct current voltage conversion boosted circuit, a resonant soft switching constant-current charging module, avoltage comparator and a feedback circuit, the energy-storage capacitor is charged to the set level through a microprocessor.

A composition for the relief of symptoms of teething in human children, and a method of its use, is disclosed. The composition includes effective amounts of the homeopathic ingredients Belladonna 3C, Chamomilla 3C and Coffea Cruda 3C, preferably combined with distilled water to form a solution. The solution is introduced into a flexible tube that is open at one end and sealed at another end. The open end is then sealed to form a water-tight pouch, which is then cooled such that the solution is frozen. In use, a pouch may be opened and the solution expelled partially from the tube in order to be orally administered to the gums of the child. The volume of solution in each pouch contains enough of the components of the solution to be effective at providing pain relief to the child experiencing teething pain, as the solution melts, while the cold temperature of the solution provides further pain relief for the child. A sweetener, artificial and natural flavors, and artificial colors may be included in the solution to enhance its taste and appearance.

A Chinese medicine in the form of capsule for treating menalgia, menoxenia and acyesis is prepared from 13 Chinese-medicinal materials including Chinese angelica root, etc through proportionally mixing, drying, grinding and loading in capsules.

Novel analogs of arachidonylethanolamide are presented which have higher affinities for the cannabinoid CB1 and / or CB2 receptor sites. Further, most of the analogs exhibit greater metabolic stability than arachidonylethanolamide. The improved receptor affinity and selectivity and / or greater metabolic stability make these analogs therapeutically useful as medications for relief of pain caused by cancer and nausea caused by chemotherapy, as well as for peripheral pain. The compounds may also be useful as oral and topical contraceptives, in suppression of the immune system, enhancement of appetite and in treatment of psychomotor disorders, multiple sclerosis and hypertension.

The invention discloses an electrode patch for treating dysmenorrhea and wearable device, and relates to the technical field of electrical stimulation treatment equipment. The electrode patch comprises an electrode carrier and a dysmenorrhea patch, the dysmenorrhea patch is arranged on the electrode carrier, the dysmenorrhea patch comprises a positive electrode plate and a plurality of negative electrode plates, the positive electrode plates and the negative electrode plates are used for being connected with the human body to generate micro-stimulation current, one positive electrode plate and the multiple negative electrode plates form a treatment area, and the treatment area acts on the dysmenorrhea part of the human body.The present invention can be used for concentrated treatment by generating plane diffraction by micro-stimulation current, the treatment area formed by the positive electrode plate and the plurality of negative electrode plates can perform nerve interference on the nerve effect of the dysmenorrhea position, and the electrode patch has the advantages that the effective pain relieving effect is achieved, and production and manufacturing are more convenient.

The invention discloses gargle. The gargle comprises 0.5-1.2 parts of paeonol, 0.6-1.0 part of eucalyptus oil, 0.8-1.5 parts of eugenol, 0.05-0.1 part of borax, 0.1-0.5 part of epsilon-polylysine, 0.04-0.09 part of borneolum syntheticum, 0.05-0.1 part of menthol, 0.05-0.08 part of natamycin, 20-27 parts of propylene glycol, 15-21 parts of hydrogenated castor oil [PEG-40 (polyethylene glycol-40)], 0.02-0.04 part of citric acid, 1.0-1.9 parts of sweetening agents and 45-62 parts of deionized water. The gargle has the advantage that strong effects of inhibiting pyogenic bacteria in oral cavities still can be realized by the gargle without chemical components such as alcohol, cetylpyridinium chloride, chlorhexidine and triclosan or hormone such as metronidazole and tinidazole under the condition of low usage of the borax.

The invention discloses a traditional Chinese medicine for treating burns and scalds, which is prepared through the following steps of: grinding 0.3-1.2 grams of moschus, 20-35 grams of ambers, 20-35 grams of pseudo-ginseng and 15-25 grams of dragon blood into power, and sufficiently stirring; adding water to a container for heating; boiling the water; stewing for half an hour, and then taking liquid medicine. The invention has simple component, convenient preparation and good treatment effect without infecting or leaving scars.

The invention relates to a formula of a traditional Chinese medicine for treating anal fissure. According to the formula, the traditional Chinese medicine is prepared from szechuan lovage rhizome, gentiana macrophylla, Chinese gall, chaff flower root, angelica dahurica, corydalis root, alum, realgar, common cnidium fruit, belvedere fruit, amur corktree bark, toona root bark, bletilla striata and 5 grams of borneol (finally added). The formula is simple and effective, and wounds can be cured quickly to achieve the healing effect.

The invention relates to a traditional Chinese medicine preparation for treating burn, and the traditional Chinese medicine preparation is a paste agent prepared from albizzia julibrissin endothelium, garden burnet, Chinese angelica, cushaw base gypsum and chicken oil as raw materials. The traditional Chinese medicine preparation is a natural traditional Chinese medicine formula, can effectively and quickly relieve pains, scabbing is quick, no scar is left, and the preparation process is simple.

The invention discloses a nursing device capable of effectively relieving pain of a patient after total hip replacement, and relates to the field of postoperative pain nursing devices. The nursing device capable of effectively relieving the pain of the patient after total hip replacement comprises a bottom plate, supporting sleeves are fixedly connected to the four corners of the top of the bottom plate, inner cavities are formed in the supporting sleeves, buffer columns are slidably connected to the interiors of the inner cavities of the supporting sleeves, buffer springs are fixedly connected to the bottoms of the buffer columns, and the buffer springs are fixedly connected to the bottoms of the buffer columns. The tops of the buffer columns are fixedly connected with a supporting buffer plate, the top of the supporting buffer plate is fixedly connected with two standing plates, and the tops of the two standing plates are fixedly connected with a nursing bed plate. According to the nursing device capable of effectively relieving the pain after total hip replacement of the patient, the hot compress bag abuts against the body of the patient all the time, the pressure on the hot compress bag and the body of the patient can be controlled and kept, the hot compress effect is guaranteed, and the pain is effectively relieved.

The invention discloses cream with a soothing effect, which comprises the following substance components in percentage by weight: water, cyclopentasiloxane and cyclohexasiloxane, shea butter, butanediol, glyceryl stearate and PE-100 stearate, C12-20 alkyl glucoside and C14-22 alcohol, hydroxyethyl acrylate / acryloyl dimethyl sodium taurate copolymer, caprylic / capric triglyceride, p-hydroxyacetophenone, 1,2-ethylene glycol, allantoin, methylparaben, chilli extract, propyl hydroxybenzoate, tocopherol acetate, EDTA disodium, ammopiptanthus mongolicus extract, safflower extract and mint extract. Extracts of the ammopiptanthus mongolicus, safflower and mint are effectively combined and applied to cosmetics, and when the cosmetics are used in hyperplasia of mammary glands or breast pain, pain canbe effectively relieved.