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Local anesthetic emulsion compositions and methods of making and using the same

A technology of local anesthetics and emulsion compositions, which can be used in the direction of anesthetics, drug combinations, emulsion delivery, etc., and can solve complex problems

Inactive Publication Date: 2012-12-26
TEIKOKU PHARMA USA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Transport across the skin membrane is therefore a complex phenomenon

Method used

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  • Local anesthetic emulsion compositions and methods of making and using the same
  • Local anesthetic emulsion compositions and methods of making and using the same
  • Local anesthetic emulsion compositions and methods of making and using the same

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Embodiment Construction

[0007] A local anesthetic emulsion composition is provided. The local anesthetic emulsion composition may comprise: an oil phase comprising a eutectic mixture of a local anesthetic and an acyclic amide; a surfactant; and an aqueous phase. Methods of making and using the emulsions are also provided.

[0008] Before the present invention is described in greater detail, it is to be understood that this invention is not limited to particular embodiments described, as such may, of course, vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting, since the scope of the invention will be defined only by the appended claims.

[0009] Where a range of values ​​is provided, it is understood that, unless the context clearly dictates otherwise, the lower limit is to the nearest tenth, each intervening value between the upper and lower limit of that range and any other value mentioned...

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Abstract

Local anesthetic emulsion compositions are provided. The local anesthetic emulsion compositions may include: an oily phase comprising a eutectic mixture of a local anesthetic and an acyclic amide; a surfactant; and an aqueous phase. Also provided are methods of making and using the emulsions.

Description

[0001] Cross References to Related Applications [0002] Pursuant to 35 U.S.C. §119(e), this application claims priority to U.S. Provisional Patent Application No. 61 / 326,613, filed April 21, 2010; the entire contents of which application are incorporated herein by reference. Background technique [0003] Drug delivery through the skin offers many advantages. First, this mode of delivery is a comfortable, convenient and non-invasive way to administer the drug. The variable rates of absorption and metabolism encountered in oral therapy are avoided, and other inherent inconveniences such as gastrointestinal irritation and the like are also eliminated. Transdermal drug delivery also allows for a high degree of control over the blood concentration of any particular drug. [0004] The skin is a structurally complex, relatively thick membrane. Molecules moving from the environment into and through the skin must first penetrate the stratum corneum and whatever is on its surface. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/00A61K45/06
CPCA61K47/18A61K47/38A61K31/167A61K47/26A61K9/0014A61K9/107A61P23/02A61P29/00A61P43/00A61K31/245A61K31/445A61K31/47
Inventor 阿德查拉·蓬皮拉帕特日比彻
Owner TEIKOKU PHARMA USA INC
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