A novel rare earth nanometer dual-mode imaging agent and its preparation method and application

A dual-mode imaging agent and rare earth technology, which is applied in the field of imaging medicine, can solve the problems of no therapeutic effect and inability to perform dual-modal imaging, and achieve better imaging effects, shortened relaxation time, and strong attenuation ability Effect

Active Publication Date: 2021-02-02
汪建华
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, currently commonly used CT or MRI contrast agents are usually not capable of bimodal imaging and have no therapeutic effect

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  • A novel rare earth nanometer dual-mode imaging agent and its preparation method and application
  • A novel rare earth nanometer dual-mode imaging agent and its preparation method and application
  • A novel rare earth nanometer dual-mode imaging agent and its preparation method and application

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Embodiment 1

[0033]A new type of rare earth nano dual-modal imaging agent, the imaging agent is NaHoF4@CeO2Nanoparticles.

[0034]A preparation method of a novel rare earth nano dual-modal imaging agent. The main experimental instruments and experimental materials in the preparation method include:

[0035]Holmium Chloride Hexahydrate (HoCl3·6H2O,>99.99%), octadecene (OED, 90%), ammonium fluoride (NH4F,>99.99%), cerium nitrite hexahydrate (Ce(NO3)3·6H2O,>99.99%) and methoxy polyethanol (DSPE-mPEG5000,>99%), purchased from Puma Biotech (Shanghai, China);

[0036]Human aortic endothelial cells (HAEC), human pancreatic cancer cells (Panc-1), provided by Shanghai Cancer Institute, Chinese Academy of Sciences;

[0037]256-slice iCT imaging instrument, produced by Philips of the Netherlands;

[0038]NIUMAG 0.5T MRI small animal imaging system, produced by Shanghai Newmai Company, China;

[0039]Varian 23EX linear accelerator, produced by Varian Company of the United States.

[0040]The preparation method includes the foll...

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Abstract

The invention discloses a novel rare earth nano dual-mode imaging agent and its preparation method and application. The imaging agent is NaHoF 4 @CeO 2 Nanoparticles, the preparation of the imaging agent comprises the following steps: one is NaHoF 4 Preparation of Nanoparticles, Second CeO 2 Preparation of nanoparticles, three in NaHoF 4 Medium-doped nano-CeO 2 And get NaHoF 4 @CeO 2 Nanoparticles, the imaging agent is used in CT and MRI dual-modal imaging. Physical and chemical characterization and toxicity experiments show that the biological safety of the nanoparticles is good. In vitro experiments show that the nanoparticles have good CT and MRI dual-modal imaging properties. State-of-the-art imaging and radiosensitization of pancreatic cancer cells.

Description

Technical field[0001]The invention relates to the technical field of imaging medicine, in particular to a novel rare earth nano bimodal imaging agent and its preparation method and application.Background technique[0002]In recent years, the development of multimodal imaging and integrated imaging agents for diagnosis and treatment has become a research focus in the field of molecular imaging. CT (Computerized Tomography) and MRI (Magnetic Resonance Imaging) have complementary advantages and are the most commonly used clinical imaging methods for tumors. CT and MRI dual-modal imaging contrast agents can improve the detection rate and diagnostic accuracy of diseases, help to more accurately outline the tumor boundary, and provide accurate positioning for further radiotherapy. At present, CT and MRI contrast agents commonly used in clinical practice cannot meet the needs of dual-modality imaging.[0003]Some scholars have conducted research on CT and MRI dual-modality imaging contrast age...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/04A61K49/18A61K33/00A61P35/00B82Y5/00B82Y15/00
CPCA61K33/00A61K49/0002A61K49/04A61K49/183A61P35/00B82Y5/00B82Y15/00
Inventor 汪建华任志豪王思齐
Owner 汪建华
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