A novel rare earth nanometer dual-mode imaging agent and its preparation method and application
A dual-mode imaging agent and rare earth technology, which is applied in the field of imaging medicine, can solve the problems of no therapeutic effect and inability to perform dual-modal imaging, and achieve better imaging effects, shortened relaxation time, and strong attenuation ability Effect
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[0033]A new type of rare earth nano dual-modal imaging agent, the imaging agent is NaHoF4@CeO2Nanoparticles.
[0034]A preparation method of a novel rare earth nano dual-modal imaging agent. The main experimental instruments and experimental materials in the preparation method include:
[0035]Holmium Chloride Hexahydrate (HoCl3·6H2O,>99.99%), octadecene (OED, 90%), ammonium fluoride (NH4F,>99.99%), cerium nitrite hexahydrate (Ce(NO3)3·6H2O,>99.99%) and methoxy polyethanol (DSPE-mPEG5000,>99%), purchased from Puma Biotech (Shanghai, China);
[0036]Human aortic endothelial cells (HAEC), human pancreatic cancer cells (Panc-1), provided by Shanghai Cancer Institute, Chinese Academy of Sciences;
[0037]256-slice iCT imaging instrument, produced by Philips of the Netherlands;
[0038]NIUMAG 0.5T MRI small animal imaging system, produced by Shanghai Newmai Company, China;
[0039]Varian 23EX linear accelerator, produced by Varian Company of the United States.
[0040]The preparation method includes the foll...
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