An Interfering Sequence of IL-17 Gene Closely Related to Podocyte Injury in Primary Nephrotic Syndrome

Abstract

The invention discloses an interference sequence of IL-17 gene closely related to podocyte damage in primary nephrotic syndrome, characterized in that: the interference sequence is SEQ ID NO.1, SEQ ID NO.2 or SEQ ID NO.2 or SEQ ID NO.2 ID NO.3. The results of this study show that silencing IL-17 by RNAi technology can effectively inhibit the expression of IL-17 gene, correct the immune imbalance of Th17 / Treg cells, alleviate IL-17-mediated podocyte damage and reduce the production of proteinuria, which has important clinical significance. Podocyte damage and proteinuria in primary nephrotic syndrome show a new perspective, with Th17 / IL-17 as a potential therapeutic target, it is expected to open up new ideas for the prevention and treatment of primary nephrotic syndrome, and for future clinical Reasonable intervention provides a theoretical basis.

Description

technical field [0001] The invention relates to an interfering sequence of IL-17 gene closely related to podocyte injury in primary nephrotic syndrome. Background technique [0002] Primary nephrotic syndrome (PNS) is a group of immune diseases of unknown etiology in childhood. Its main clinical manifestation is a large amount of proteinuria, which then leads to persistent renal damage and eventually renal failure. It brings great physical and mental and economic burdens to the family and society. In previous studies, its clinical features, pathological features, and prognosis have been clarified, but its specific pathogenesis has not yet been fully understood. [0003] Previous studies believed that Th1 / Th2 cells play an important role in a variety of autoimmune diseases, but a large number of studies in recent years have shown that their mediated effector mechanism cannot fully explain the complex pathogenesis. The discovery of new Th17 cells, Th17 / Treg Cell balance makes...

AI Technical Summary

Problems solved by technology

[0002] Primary nephrotic syndrome (PNS) is a group of immune diseases of unknown etiology in childhood. Its main clinical manifestation is a large amount of proteinuria, which then leads to persistent renal damage and eventually renal failure. Family and society bring great physical and mental and economic burdens. In previous studies, its clinical features, pathological features, prognosis, etc. have been clarified, but its specific pathogenesis has not yet been fully understood.

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