Application of isopimaric acid in preparation of anti-tumor drug

Abstract

The invention discloses an application of isopimaric acid in preparation of an anti-tumor drug. It is found that Haitong abietane diterpene E, Haitong abietane diterpene F, Haitong abietane diterpeneG, Haitong abietane diterpene H, kirenol, isopimaran-19-ol, pimara-dien-acid and isopimaric acid have inhibition functions on gallbladder carcinoma SNU-308 cells and multiple myeloma ARH-77 cells; 12-hydroxykirenol only has excellent inhibition functions on multiple myeloma ARH-77 cells; 9(11),15-isopimaradiene-3beta,19-diol only has excellent inhibition functions on gallbladder carcinoma SNU-308cells. Therefore, the compound can be used for preparing antitumor drugs.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the discovery and development of antitumor drugs, in particular to the discovery and development of gallbladder cancer and multiple myeloma drugs. Background technique [0002] Malignant tumor is one of the main factors threatening human health today, and its case fatality rate is increasing year by year in our country, and it has become the first cause of death in our country. At present, the methods for treating malignant tumors mainly include surgery, radiotherapy and chemotherapy, and targeted therapy. [0003] Gallbladder cancer is a malignant tumor derived from gallbladder epithelial cells. It is easy to metastasize, has poor prognosis, and has atypical early symptoms. Clinically, most patients are diagnosed in the middle and advanced stages. Currently, there are limited treatment options for gallbladder cancer, and surgical resection is the only effective radical cure. Therefore, it ...

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Problems solved by technology

[0009] The application of the compound with the above-mentioned structure in the tr

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