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Application of plasma/serum exosomal miRNAs as glaucoma diagnostic markers

A technology for primary glaucoma and disease diagnosis, applied in biochemical equipment and methods, microbial determination/examination, etc., to achieve far-reaching clinical significance and popularization effects

Active Publication Date: 2019-12-24
WENZHOU MEDICAL UNIV
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  • Abstract
  • Description
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Problems solved by technology

At present, clinical treatment mainly focuses on lowering intraocular pressure and neuroprotection, but about 10% of patients are blind eventually, and the inability to effectively control the progressive apoptosis of retinal ganglion cells (RGCs) and promote post-injury repair and regeneration is the bottleneck.

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  • Application of plasma/serum exosomal miRNAs as glaucoma diagnostic markers
  • Application of plasma/serum exosomal miRNAs as glaucoma diagnostic markers
  • Application of plasma/serum exosomal miRNAs as glaucoma diagnostic markers

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Embodiment Construction

[0033] The present invention will be described in further detail below in conjunction with the accompanying drawings and embodiments, without limiting the present invention.

[0034] 1.1 Preparation of experimental group specimens:

[0035] The blood samples of 231 patients were collected from outpatients or inpatients of the Eye Hospital Affiliated to Wenzhou Medical University from April 2016 to March 2018, including 80 cases of primary open-angle glaucoma and primary angle-closure glaucoma. 131 cases. During the same period, 120 cases of simple cataract control group were collected. Patients with systemic diseases, other eye diseases and surgeries were excluded from the subjects, chronic diseases such as diabetes and hypertension, and patients with systemic diseases such as infection were excluded; other eye diseases or surgeries were excluded history patients. The situation of the cases is shown in Table 1. The abbreviations that appear below represent respectively: PA...

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Abstract

The invention discloses application of has-miR-21-5p and / or has-miR-15b-5p and / or has-miR-424-5p as a diagnostic marker for glaucoma. Research experiments show that the has-miR-21-5p and / or the has-miR-15b-5p and / or the has-miR-424-5p are up-regulated in expression of exosomes isolated from blood of a patient with primary glaucoma. The application of the has-miR-21-5p and / or the has-miR-15b-5p and / or the has-miR-424-5p expression level products in the preparation of a diagnostic tool for the glaucoma is provided.

Description

technical field [0001] The invention relates to the technical field of molecular diagnosis, in particular to the application of plasma / serum exosome miRNA in the preparation of glaucoma disease diagnostic tools. Background technique [0002] Vision is the most important sense of humans and animals, and at least 80% of the external information is obtained through vision. Glaucoma is the second blinding eye disease and the first irreversible blinding eye disease in the world. It is a neurodegenerative disease that causes optic nerve atrophy, visual field defect, and eventually blindness due to various reasons such as pathological high intraocular pressure. At present, clinical treatment mainly focuses on lowering intraocular pressure and neuroprotection, but about 10% of patients are blind eventually. The bottleneck lies in the failure to effectively control the progressive apoptosis of retinal ganglion cells (RGCs) and promote the repair and regeneration after injury. Glauco...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/118C12Q2600/158C12Q2600/178
Inventor 池在龙张文梦关吉田
Owner WENZHOU MEDICAL UNIV
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