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Serum miRNA marker related to squamous cell lung carcinoma auxiliary diagnosis, and application thereof

A technology of auxiliary diagnosis and markers, which is applied in the fields of genetic engineering and oncology, can solve the problems of incompletely consistent research results and achieve high sensitivity and specificity, good stability, and easy access

Active Publication Date: 2018-02-23
朱伟
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, due to differences in research methods and included populations, the results of the studies were not completely consistent.

Method used

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  • Serum miRNA marker related to squamous cell lung carcinoma auxiliary diagnosis, and application thereof
  • Serum miRNA marker related to squamous cell lung carcinoma auxiliary diagnosis, and application thereof
  • Serum miRNA marker related to squamous cell lung carcinoma auxiliary diagnosis, and application thereof

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Experimental program
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Embodiment Construction

[0037] The inventor collected a large number of venous plasma samples from the First Affiliated Hospital of Nanjing Medical University from 2012 to 2015, and selected 102 cases of lung squamous cell carcinoma and 101 cases of The normal control sample was used as the experimental sample for the initial screening of Exiqon miRNA qPCR panel chip and subsequent series of qRT-PCR verification. At the same time, 23 cases of lung squamous cell carcinoma tissues and 23 cases of paracancerous tissues were retained. The selected patients' plasma samples were all from newly diagnosed patients who had not undergone surgery, radiotherapy and chemotherapy, and were pathologically confirmed as squamous cell carcinoma of the lung. The demographic data and clinical data of these samples were collected systematically.

[0038] Refer to the flowchart ( figure 1 ), randomly selected 30 lung squamous cell carcinoma samples and 10 normal controls from the plasma samples of lung squamous cell car...

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Abstract

The invention discloses a serum miRNA marker related to squamous cell lung carcinoma auxiliary diagnosis, and application thereof. The marker is one or more of miR-181a-5p,miR-21-5p,miR-106a-5p and miR-93-5p The serum miRNA marker has the characteristics of being good in stability, easily available in minimally invasive surgery, and high in sensitivity and specificity as a novel biomarker. The development and utilization of the molecular marker can provide a new direction for diagnosis and further treatment of various diseases including tumors. The study can more pertinently obtain squamous cell lung carcinoma serum miRNA marker with clinical diagnosis potential. The study proves the reliability and repeatability of the group of miRNA as a non-invasive marker for diagnosing squamous cell lung carcinoma.

Description

technical field [0001] The invention belongs to the fields of genetic engineering and oncology, and relates to a plasma miRNA marker related to the auxiliary diagnosis of lung squamous cell carcinoma and its application. Background technique [0002] Lung cancer is one of the most common malignant tumors in the world. In China, the morbidity and mortality of lung cancer rank first. Non-small cell lung cancer (NSCLC) accounts for approximately 85% of lung cancers. Among them, squamous cell carcinoma of the lung is one of the most common subtypes of NSCLC. Although surgical treatment is currently the first choice and the most important treatment for squamous cell carcinoma of the lung, and can achieve the goal of curing early squamous cell carcinoma of the lung, the early diagnosis rate in my country is still low due to the lack of specificity in the early clinical manifestations of squamous cell carcinoma of the lung. lower. At present, low-dose computed tomography (LDCT) ...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886C12N15/113C12N15/11
Inventor 朱伟周鑫张澜张获闻伟王同杉刘平
Owner 朱伟
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