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A plasma miRNA marker related to auxiliary diagnosis of lung adenocarcinoma and its application

A technology for auxiliary diagnosis and lung adenocarcinoma, applied in the fields of genetic engineering and oncology, it can solve the problems such as the need to strengthen the detection sensitivity and specificity, rely on the experience of the tester, and cannot be promoted due to the high price, so as to achieve high sensitivity and specificity, Easy and minimally invasive effects

Active Publication Date: 2019-10-01
朱伟
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Problems solved by technology

At present, research on the molecular and clinical characteristics of lung cancer continues to deepen, and clinical screening and treatment methods have also made great progress. However, these methods are either too dependent on the experience of the tester, or the price is too high to be popularized, or the detection sensitivity and specificity need to be strengthened

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  • A plasma miRNA marker related to auxiliary diagnosis of lung adenocarcinoma and its application
  • A plasma miRNA marker related to auxiliary diagnosis of lung adenocarcinoma and its application
  • A plasma miRNA marker related to auxiliary diagnosis of lung adenocarcinoma and its application

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Embodiment Construction

[0040] From 2012 to 2014, the inventor collected a large number of venous plasma samples from patients with lung adenocarcinoma and normal physical examination population from the First Affiliated Hospital of Nanjing Medical University, and selected 141 cases of lung adenocarcinoma and 124 cases of The normal control sample was used as the experimental sample for the initial screening of Exiqon miRNA qPCR panel chip and subsequent series of qRT-PCR verification. At the same time, 19 pairs of lung adenocarcinoma and adjacent tissues, as well as 5 arterial plasma samples were collected. The selected patients' plasma samples were all from newly diagnosed patients who had not undergone surgery, radiotherapy and chemotherapy intervention and were confirmed as lung adenocarcinoma by pathology. The demographic data and clinical data of these samples were collected systematically.

[0041] Refer to the flowchart ( figure 1 ), randomly selected 30 lung adenocarcinoma samples and 10 n...

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Abstract

The invention discloses a plasma miRNA marker relevant to lung adenocarcinoma auxiliary diagnosis and the application thereof. The marker is one or more of miR-19b-3p, miR-21-5p, miR-221-3p, miR-409-3p, miR-425-5p and miR-584-5p. Plasma miRNA serving as the novel biological marker has the advantages of being high in stability, minimally invasive, easy to obtain and high in sensitivity and specificity. Development and utilization of the molecular marker can provide a new direction for diagnosis and further treatment of diseases including tumor. Through the research, a lung adenocarcinoma plasma miRNA marker with clinical diagnosis potential can be obtained in a more targeted mode. Research proves the reliability and repeatability of the group of miRNA as a noninvasive marker for diagnosis of lung adenocarcinoma.

Description

technical field [0001] The invention belongs to the fields of genetic engineering and oncology, and relates to a plasma miRNA marker related to the auxiliary diagnosis of lung adenocarcinoma and its application. Background technique [0002] Lung cancer is a malignant tumor with the highest mortality rate in the world, and non-small cell lung cancer (NSCLC) accounts for 80% of the total number of lung cancers. Non-small cell lung cancer can be divided into lung adenocarcinoma and lung squamous cell carcinoma according to pathological classification, and the incidence of lung adenocarcinoma has surpassed that of lung squamous cell carcinoma and has become the most common type of lung cancer. Surgical treatment is still the most effective method for the treatment of non-small cell lung cancer. However, the vast majority of patients are already in the middle and advanced stages when they see a doctor, so that the median survival period is always hovering at 7-11 months, and th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6886C12N15/113C12N15/11
Inventor 朱伟周鑫束永前刘平闻伟陈彦齐炼文单霞
Owner 朱伟
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