Application of combination of zoledronic acid and organic selenium compound in the preparation of antitumor drugs

An anti-tumor drug, zoledronic acid technology, applied in the field of tumor treatment, can solve the problems of tumor cell apoptosis, DNA damage, cell cycle arrest, etc., and achieve the effect of efficiently inducing apoptosis
CN109908159BActive Publication Date: 2021-12-07JINAN UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JINAN UNIVERSITY
Publication Date
2021-12-07

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Abstract

The invention discloses the combined use of zoledronic acid and an organic selenium compound in the preparation of antitumor drugs. In the in vitro cell experiment of the present invention, it is found that the inhibitory effect of a single organic selenium compound and a single zoledronic acid on tumor cells is obviously inferior to that of combined drugs, indicating that the combination of the two can form a synergistic effect, that is, the organic selenium compound and zoledronic acid can be used The synergistic effect of acid achieves the purpose of efficiently inducing tumor cell apoptosis. In the present invention, it is also found that the potential mechanism of zoledronic acid enhancing organoselenium compounds to inhibit the growth of prostate cancer cells is caused by inducing cells to produce excessive ROS. Therefore, zoledronic acid and organic selenium compounds can be used in combination to prepare antitumor drugs, or zoledronic acid can be used as a sensitizer of organic selenium compounds in the field of tumor treatment.
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Description

technical field

[0001] The invention relates to the technical field of tumor treatment, in particular to the combined use of zoledronic acid and an organic selenium compound in the preparation of antitumor drugs. Background technique

[0002] Prostate cancer is one of the common malignant tumors of the male genitourinary system, and the incidence rate is increasing year by year and tends to be younger. Because the onset of prostate cancer is hidden, its symptoms are often ignored. When it is diagnosed, about 65% to 75% have already There is bone metastases. Prostate cancer bone metastasis will cause a series of bone-related diseases, including pathological fractures, spinal cord compression, malignant tumor hypercalcemia, etc. Bone pain is the most common symptom of advanced prostate cancer, which seriously affects the quality of life of patients. Therefore, how to improve the treatment effect while relieving the patient's pain and ensuring the quality of life of the patien...

Claims

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