use the human body 18 f-fdg PET data analysis tissue DNA hydroxymethyl background and application

A 18F-FDG, data analysis technology, applied in the fields of medicine, biology and general health, can solve problems such as large differences, and achieve the effect of simple method, easy popularization and application, and strong operability

Active Publication Date: 2021-03-02
煋晟医疗技术(杭州)有限公司
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Problems solved by technology

However, due to the large differences in tissue cells in the body and the different effects of the environment on the target organs of the human body, these single-cell or single-tissue detection methods cannot achieve a non-invasive description of the DNA of the entire human body Methylation background

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  • use the human body <sup>18</sup> f-fdg PET data analysis tissue DNA hydroxymethyl background and application
  • use the human body <sup>18</sup> f-fdg PET data analysis tissue DNA hydroxymethyl background and application
  • use the human body <sup>18</sup> f-fdg PET data analysis tissue DNA hydroxymethyl background and application

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Embodiment Construction

[0060] The present invention will be further described below in conjunction with the accompanying drawings.

[0061] A human body as described in the accompanying drawing 18 F-FDG PET data analysis tissue DNA hydroxymethyl background, including the following steps:

[0062] (1) Get an adult 18 F-FDG whole body tomographic image;

[0063] (2) Use the ROI method or the SUV value method to extract the 18 F-FDG data and calculated glucose uptake rates, and formed by sex-age 18 A database of F-FDG uptake rates;

[0064] (3) Correct the DNA telomere linear shortening curve according to the background and fitting of each target organ tissue database of normal adults, and establish a working module for analyzing and measuring the DNA hydroxymethyl background;

[0065] (4) Determination of tissue-specific primary parameters of DNA hydroxymethyl background, and secondary parameters of DNA hydroxymethyl background derived from the primary parameters of DNA hydroxymethyl background. ...

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Abstract

The invention discloses a human body 18 F‑FDG PET Data Analysis Tissue DNA Hydroxymethyl Background and Applications, Including Obtaining Adults 18 F‑FDG whole-body tomographic image; extract 18F‑FDG data of each target tissue and calculate glucose uptake rate, and form a gender-age-corresponding 18 The database of F-FDG uptake rate; according to the background and fitting of each target organ tissue database of normal adults, the DNA telomere linear shortening curve is corrected, and the working module for analyzing and measuring the DNA hydroxymethyl background is established; the tissue-specific DNA hydroxymethyl is determined Background primary parameters, and tissue-specific DNA hydroxymethyl background secondary parameters. The present invention provides a method for non-invasive analysis and determination of DNA hydroxymethyl background specific to whole body tissues, which can provide effective genetic and molecular information support for personalized prevention and rehabilitation of chronic diseases, as well as personalized health care and precision medical research and development.

Description

technical field [0001] The invention relates to the fields of medical biology and general health, in particular to a human body 18 F-FDG PET data analysis tissue DNA hydroxymethyl background and application. Background technique [0002] Major chronic diseases have become a major threat to human health, mainly including cardiovascular and cerebrovascular diseases, cancer, chronic respiratory diseases, diabetes and oral diseases, as well as endocrine, kidney, bone, nerve and other diseases. [0003] 80% of the causes of major chronic diseases are attributed to the adverse environment inside and outside the human body, including cell aging, harmful substances, inflammatory factors, bad living habits, unscientific nutrition, lack of exercise, and environmental stress. The epigene (group) is the bridge between the environment and chronic diseases. Deviating from the normal tissue-specific gene methylation background, which is a characteristic manifestation of epigenetic abnorm...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16H50/30G16H50/70
CPCG16H50/30G16H50/70
Inventor 曾骏
Owner 煋晟医疗技术(杭州)有限公司
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