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Drugs to alleviate neonatal microcephaly associated with Zika virus infection

A technology of Zika virus and medicine, applied in the field of medicine for neonatal microcephaly

Active Publication Date: 2021-12-14
INST OF PATHOGEN BIOLOGY CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is still no specific drug for ZIKV infection and viral infection-related fetal and neonatal nervous system diseases

Method used

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  • Drugs to alleviate neonatal microcephaly associated with Zika virus infection
  • Drugs to alleviate neonatal microcephaly associated with Zika virus infection
  • Drugs to alleviate neonatal microcephaly associated with Zika virus infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1. Application of DHA in alleviating microcephaly associated with Zika virus infection

[0041] 1. BALB / C mice were randomly divided into model group and control group (12 mice in each group) on the 0th day of birth, and the following operations were performed:

[0042] Model group (ZIKV): Take the Zika virus SZ01 virus stock solution and dilute it with fresh DMEM basal medium to a virus solution with a final concentration of 100 PFU per 20 μL, use a 50 μL micro-sterile syringe to draw 20 μL of the above virus solution and inject it into the brain of the newborn mouse lambda region.

[0043] Control group (Mock): Use a 50 μL micro sterile syringe to draw 20 μL of PBS and inject it into the λ region of the neonatal mouse brain.

[0044] 2. After completing step 1, each group of the model group (ZIKV) and the control group (Mock) was randomly divided into a control DMSO group and a DHA group (6 rats in each group), as follows:

[0045] Model DHA group (ZIKV-DHA)...

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Abstract

The invention discloses a medicine for alleviating microcephaly in newborns associated with Zika virus infection. The invention protects the application of docosahexaenoic acid in the preparation of products; the purpose of the product is to prevent and / or treat microcephaly in newborns caused by Zika virus infection. The invention has great significance for the prevention and treatment of neonatal microcephaly associated with Zika virus infection.

Description

technical field [0001] The invention relates to a medicine for alleviating microcephaly in newborns associated with Zika virus infection. Background technique [0002] Zika virus (ZIKV) is an emerging arbovirus that was first discovered and isolated in 1947 in a febrile sentinel rhesus monkey in the Zika forest area of ​​Uganda. In 1952, a study in Uganda and the United Republic of Tanzania identified the first human cases of ZIKV infection. Since its discovery more than 70 years ago, ZIKV has spread widely around the world. Most of the tropical and subtropical areas in the world where more than 2 billion people live have suitable environmental conditions for ZIKV transmission, and there are a large number of susceptible people. Combined with the rapid spread due to travel, these areas have a higher risk of ZIKV introduction and establishment of new indigenous transmissions. In recent years, due to the increase in the number of imported cases related to travel, the first i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/202A61P31/14A61P25/00
CPCA61K31/202A61P31/14A61P25/00Y02A50/30
Inventor 杨威周佳迟晓静秦成峰
Owner INST OF PATHOGEN BIOLOGY CHINESE ACADEMY OF MEDICAL SCI
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